Concentration-dependent effects of TEA-Cl on normalized TRESK outward currents

    Data were kindly provided by SB DrugDicsovery

TRESK | Potassium Channel Subfamily K Member 18

Tandem-Pore Domain Potassium Channels

Tandem pore domain K+ channels have been classified into six subfamilies; tandem pore domains in weak rectifying K+ channel (TWIK), TWIK-related K+ channel (TREK), TWIK-related acid-sensitive K+ channel (TASK), TWIK-related alkaline pH-activated K+ channel (TALK), tandem pore domain halothane-inhibted K+ channel (THIK), TWIK-releated spinal cord K+ channel (TRESK)
15 members: K2P1.1 (TWIK-1); K2P2.1 (TREK-1); K2P3.1 (TASK-1); K2P4.1 (TRAAK); K2P5.1 (TASK-2); K2P6.1 (TWIK-2); K2P7.1; K2P9.1 (TASK-3); K2P10.1 (TREK-2); K2P12.1 (THIK-2); K2P13.1 (THIK-1); K2P15.1 (TASK-5); K2P16.1 (TALK-1); K2P17.1 (TASK-2, TASK-4); K2P18.1 (TRIK, TRESK);

The channel protein contains four transmembrane domains, which form two pore loops between domains 1–2 and 3–4. Two subunits associate to form a dimer with bilateral symmetry around the pore. Homodimers and heterodimers are possible.

Several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins


2016 - Human T cells in silico: Modelling their electrophysiological behaviour in health and disease

icon pl  Patchliner publication in Journal of Theoretical Biology (2016)

Ehling P., Meuth P., Eichinger P., Hermann A.M., Bittner S., Pawlowski M., Pankratz S., Herty M., Budde T., Meuth S.G.

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