TRIC-A / TRIC-B | Trimeric Intracellular Cation Channel Type A / B
Family:
Trimeric Intracellular Cation Channels, also known as TMEM38 family
Subgroups:
2 members: TRIC-A, TRIC-B
Topology:
Each TRIC subunit contains three transmembrane domains, a cytoplasmic C-terminus and a luminal N-terminus. Functional entities are formed by homotrimerizarion.
Function:
Modulate the release of Ca2+ through the ryanodine receptor or inositol triphosphate receptor, and maintain the homeostasis of ions within sarcoplasmatic and endoplasmatic lumen
Publications
2017 - Ion- and water-binding sites inside an occluded hourglass pore of a trimeric intracellular cation (TRIC) channel
Vesicle Prep Pro publication in BioMed Central Biology (2017)
Authors:
Ou X., Guo J., Wang L., Yang H., Liu X., Sun J., Liu Z.
2016 - Pore architecture of TRIC channels and insights into their gating mechanism
Port-a-Patch and Vesicle Prep Pro publication in Nature (2016)
Authors:
Yang H., Hu M., Guo J., Ou X., Cai T., Liu Z.