• TRIC Channels

    Electrophysiological recording of the TRIC channel from Sulfolobus solfataricus. GUVs were prepared with the Vesicle Prep Pro.

    Ou et al. (2017)

TRIC-A / TRIC-B | Trimeric Intracellular Cation Channel Type A / B

Trimeric Intracellular Cation Channels, also known as TMEM38 family

2 members: TRIC-A, TRIC-B

Each TRIC subunit contains three transmembrane domains, a cytoplasmic C-terminus and a luminal N-terminus. Functional entities are formed by homotrimerizarion.

Modulate the release of Ca2+ through the ryanodine receptor or inositol triphosphate receptor, and maintain the homeostasis of ions within sarcoplasmatic and endoplasmatic lumen


2017 - Ion- and water-binding sites inside an occluded hourglass pore of a trimeric intracellular cation (TRIC) channel

icon vpp   Vesicle Prep Pro publication in BioMed Central Biology (2017)

Ou X., Guo J., Wang L., Yang H., Liu X., Sun J., Liu Z.

2016 - Pore architecture of TRIC channels and insights into their gating mechanism

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Nature (2016)

Yang H., Hu M., Guo J., Ou X., Cai T., Liu Z.

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