• TRIC Channels

    Electrophysiological recording of the TRIC channel from Sulfolobus solfataricus. GUVs were prepared with the Vesicle Prep Pro.

    Ou et al. (2017)

TRIC-A / TRIC-B | Trimeric Intracellular Cation Channel Type A / B

Family:
Trimeric Intracellular Cation Channels, also known as TMEM38 family

Subgroups:
2 members: TRIC-A, TRIC-B

Topology:
Each TRIC subunit contains three transmembrane domains, a cytoplasmic C-terminus and a luminal N-terminus. Functional entities are formed by homotrimerizarion.

Function:
Modulate the release of Ca2+ through the ryanodine receptor or inositol triphosphate receptor, and maintain the homeostasis of ions within sarcoplasmatic and endoplasmatic lumen

Publications

2017 - Ion- and water-binding sites inside an occluded hourglass pore of a trimeric intracellular cation (TRIC) channel

icon vpp   Vesicle Prep Pro publication in BioMed Central Biology (2017)

Authors: 
Ou X., Guo J., Wang L., Yang H., Liu X., Sun J., Liu Z.

2016 - Pore architecture of TRIC channels and insights into their gating mechanism

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Nature (2016)

Authors: 
Yang H., Hu M., Guo J., Ou X., Cai T., Liu Z.

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