• TRPM2

    Mean concentration-response data for rosiglitazone inhibition of TRPM3 activated by 5 μM PregS or TRPM2 activated by 1 mM H2O2

    Majeed et al. (2011)

TRPM2 | Transient Receptor Potential Cation Channel Subfamily M Member 2

Family:
Transient  receptor potential channels

Subgroups:
TRPC (TRPC1–TRPC7), TRPV (TRPV1-TRPV6), TRPA1, TRPM (TRPM1–TRPM8), TRPP (TRPP1–TRPP3, PKD1, PKDREJ, PKDL1–PKDL3), TRPML (TRPML1–TRPML3), TRPN

Topology:
Most TRP channels are composed of 6 transmembrane domains (helices) with intracellular N- and C-termini, non-selectively permeable to various cations

TRPM2: Background information

Gene:
SCN10A

Human Protein:
UniProt Q9Y5Y9

Tissue:
Brain (small diameter DRG neurons)

Function/ Application:
Excitability of neurons, nociceptive transmission

Pathology:
Neuropathic pain, Multiple Sclerosis

Accessory subunits:
b1, b2, b3

Interaction:
p11, PDZD2 and syntrophin-associated serine/threonine kinase (SASTK), Contactin, CAP-1A

Modulator:
Tetrodotoxin, lidocaine, benzocaine, A-887826, A-803467

Assays:
Patch Clamp: whole cell, room temperature, State- and use-dependence

Particularities:

Cell systems:
hNaV1.8 stably expressing CHO cell line (Charles River); rNaV1.8 stably expressed in ND7/23 cell line (EMD Millipore)

Recommended Reviews:
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 57: 397–409, Catterall, et al. 2005 

Publications

2011 - Rapid and Contrasting Effects of Rosiglitazone on Transient Receptor Potential TRPM3 and TRPC5 Channels

icon pl  Patchliner publication in Molecular Pharmacology (2011)

Authors: 
Majeed Y., Bahnasi Y., Seymour V.A.L., Wilson L.A., Milligan C.J., Agarwal A.K., Sukumar P., Naylor J., Beech D.J.

Cookies make it easier for us to provide you with our services. With the usage of our services you permit us to use cookies.
More information Ok