TRPM3 | Transient Receptor Potential Cation Channel Subfamily M Member 3
Transient receptor potential channels
TRPC (TRPC1–TRPC7), TRPV (TRPV1-TRPV6), TRPA1, TRPM (TRPM1–TRPM8), TRPP (TRPP1–TRPP3, PKD1, PKDREJ, PKDL1–PKDL3), TRPML (TRPML1–TRPML3), TRPN
Most TRP channels are composed of 6 transmembrane domains (helices) with intracellular N- and C-termini, non-selectively permeable to various cations
TRPM3: Background information
TRPM3, also called Long Transient Receptor Potential Channel 3, is a cation-selective channel important for cellular calcium signaling and homeostasis. TRPM3 mediates calcium entry, and this entry is potentiated by calcium store depletion. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. TRPM3 was shown to be activated by the neurosteroid pregnenolone sulphate in pancreatic beta cell. The activation causes calcium influx and subsequent insulin release, therefore it is suggested that TRPM3 modulates glucose homeostasis.
Kidney, brain, testis, ovary, pancreas, spinal cord
Glucose hemostase, calcium entry into cells upon calcium store depletion, renal calcium homeostasis
Dentin sensitivity, Chronic Fatigue Syndrome.
Oncostatin M, Actin, alpha 2
Nifedipine, mefenamic acid, pioglitazone, sphingosine, pregnenolone sulphate
Patch Clamp: whole cell
Recommended Reviews:International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels., Pharmacol Rev 55(4):591-6 Clapham, et al. 2003