TRPM7 | Transient Receptor Potential Cation Channel Subfamily M Member 7

TRPM7 is a divalent cation channel permeable to calcium and magnesium. The protein encoded by this TRPM7 is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis.

Gene:
TRPM7

Human Protein:
UniProt Q96QT4

Tissue:
Widely expressed in mammalian cells, especially heart, pituitary, bone, adipose tissue, highest expression level in kidney

Function/ Application:
TRPM7 has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Furthermore, the channel is involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx and it may be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell.

Pathology:
Ophthalmomyiasis, Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, dementia, lateral sclerosis, cardiac fibrosis, atrial fibrillation, macrothrombocytopenia. TRPM7 plays a role in cancer cells including survival, cell cycle progression, proliferation, growth, migration, invasion, and epithelial-mesenchymal transition (EMT)

Interaction:
PLCB1, PLCB2, phosphorylates annexin 1, forms complexes in synaptic vesicles with synapsin I and synaptotagmin I and directly interacts with snapin, TRPM7 forms heterodimers with TRPM6.

Modulator:
carvacrol, H⁺ (extracellular), ADP, naltriben, PiP₂, 2-APB, spermine, fingolimod, La³⁺

Assays:
Patch Clamp: whole cell

Recommended Reviews:
International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels., Pharmacol Rev 55(4):591-6 Clapham, et al. 2003