TRPV2 | Transient Receptor Potential Cation Channel Subfamily V Member 2

Family:
Transient receptor potential channels

Subgroups:
TRPC (TRPC1–TRPC7), TRPV (TRPV1-TRPV6), TRPA1, TRPM (TRPM1–TRPM8), TRPP (TRPP1–TRPP3, PKD1, PKDREJ, PKDL1–PKDL3), TRPML (TRPML1–TRPML3), TRPN

Topology:
Most TRP channels are composed of 6 transmembrane domains (helices) with intracellular N- and C-termini, non-selectively permeable to various cations

TRPV2: Background information

Gene:
SCN10A

Human Protein:
UniProt Q9Y5Y9

Tissue:
Brain (small diameter DRG neurons)

Function/ Application:
Excitability of neurons, nociceptive transmission

Pathology:
Neuropathic pain, Multiple Sclerosis

Accessory subunits:
b1, b2, b3

Interaction:
p11, PDZD2 and syntrophin-associated serine/threonine kinase (SASTK), Contactin, CAP-1A

Modulator:
Tetrodotoxin, lidocaine, benzocaine, A-887826, A-803467

Assays:
Patch Clamp: whole cell, room temperature, State- and use-dependence

Particularities:

Cell systems:
hNa_V1.8 stably expressing CHO cell line (Charles River); rNa_V1.8 stably expressed in ND7/23 cell line (EMD Millipore)

Recommended Reviews:
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 57: 397–409, Catterall, et al. 2005

Publications

2012 - Calcium regulation by thermo- and osmosensing transient receptor potential vanilloid channels (TRPVs) in human conjunctival epithelial cells

Port-a-Patch publication in Histochemistry and Cell Biology (2012)

Authors:
Mergler S., Garreis F., Sahlmüller M., Lyras E.-M., Reinach P.S., Dwarakanath A., Paulsen F., Pleyer U.

2011 - Thermosensitive transient receptor potential channels in human corneal epithelial cells

Port-a-Patch publication in Journal of Cellular Physiology (2011)

Authors:
Mergler S., Garreis F., Sahlmüller M., Reinach P.S., Paulsen F., and Pleyer U.

2010 - TRPV channels mediate temperature-sensing in human corneal endothelial cells

Port-a-Patch publication in Experimental Eye Research (2010)

Authors:
Mergler S., Valtink M., Coulson-Thomas V.J., Lindemann D., Reinach P.S., Engelmann K., Pleyer U.