TRPV3 | Transient Receptor Potential Cation Channel Subfamily V Member 3
Transient receptor potential channels
TRPC (TRPC1–TRPC7), TRPV (TRPV1-TRPV6), TRPA1, TRPM (TRPM1–TRPM8), TRPP (TRPP1–TRPP3, PKD1, PKDREJ, PKDL1–PKDL3), TRPML (TRPML1–TRPML3), TRPN
Most TRP channels are composed of 6 transmembrane domains (helices) with intracellular N- and C-termini, non-selectively permeable to various cations
TRPV3: Background information
TRPV3 is a putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (22°C - 40°C) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification.
Widely expressed in the human body, abundantly expressed in the CNS, keratinocyte layers of the outer root sheath and matrix of the hair follicles
TRPV3 plays a role in a variety of processes, including temperature sensation and vasoregulation. TRPV3 is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen)
Olmsted syndrome (OLMS), Palmoplantar keratoderma, non-epidermolytic, focal 2 (FNEPPK2).
Selective TRPV3 inhibition is being investigated for therapeutic potential for treatment of chronic pruritus, skin allergy, or inflammation-related skin diseases.
TRPV3 may form a heteromeric channel with TRPV1, and it interacts with Calmodulin, epidermal growth factor receptor, AKAP79 (AKAP-5)
Carvacrol, thymol, eugenol, camphor, 2-APB, isopentenyl diphosphate, aspirin-triggered resolvin D1, forsythoside B, isopentenyl diphosphate, osthole, ruthenium red
Patch Clamp: whole cell, temperature control
Recommended Reviews:International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels., Pharmacol Rev 55(4):591-6 Clapham, et al. 2003