Hypotonicity-induced TRPV4 channel activation, measured on the Port-a-Patch

    Mergler et al. (2011)

TRPV4 - Activation and inhibition of TRPV4 using different stimuli on the Port-a-Patch

icon pap   Port-a-Patch application note:   logo pdf   (3.79 MB) 


TRPV4 is a member of the transient receptor potential TRPV4 is a member of the transient receptor potential channel (TRP) family. Transient receptor potential vanilloidtype 4 (TRPV4) shares approximately 40% identity with TRPV1 and TRPV2 and is a Ca2+-permeable non-selectivecation channel1-3 expressed in a wide range of tissues including neurons of the central and peripheral nervous systems, and in non-neuronal tissue including human T cells, corneal and retinal epithelial cells, endothelial cells of the eye, liver, heart, kidney, synoviocytes, epitheliallining of trachea and lung airways, stellate cells of thepancreas, and many more.

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