Whole cell patch clamp recordings of VRAC were performed with resting and activated CD4+ T cells

    Ehling et al. (2016)

VRACs | Volume-regulated Anion Channels

Volume-regulated anion channels

VRACs are composed of LRRC8 protein heteromers (possibly to form a heterohexamer), of which there are five variations: LRRC8A, LRRC8B, LRRC8C, LRRC8D, and LRRC8E. LRRC8 proteins (Leucine-rich repeat containing 8) contain four transmembrane helices.

Regulation and Function:
(VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane. Furthermore, the channels play a crucial role in cell proliferation, migration, and apoptosis. Besides chloride ions and osmolytes, VRACs are known to be as well water-permeable.


2016 - Human T cells in silico: Modelling their electrophysiological behaviour in health and disease

icon pl  Patchliner publication in Journal of Theoretical Biology (2016)

Ehling P., Meuth P., Eichinger P., Hermann A.M., Bittner S., Pawlowski M., Pankratz S., Herty M., Budde T., Meuth S.G.



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