Our collaboration partner Nexel is offering iPSC-derived cells for Assays on Nanion's Instruments

NEXEL logo

NEXEL is progressing with a sense of mission to make a better world through the commercialization of stem cell research. With NEXEL’s cutting-edge technologies, NEXEL manufactures human cell products derived from iPS Cell to develop more efficient tools for new drug discovery / development, and various innovative applications.


The following cells were validated on Nanion's Instruments:

Cardiac cells
NEXEL’s Cardiosight-S® provides a highly pure (≥95%) and mature population of cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSC) with validated human cardiac characteristics and functions. These cardiomyocytes accurately and reproducibly predict human cardiac toxicity in vitro, proving a useful tool for safety pharmacology testing and drug screening. They also support various research platforms such as 3D bioprinting, lab-on-a-chip, and organoid.


Collaborative Activities with Nexel

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Cardiac Action Potentials - Digoxin Concentration response curves

FLEXcyte Digoxin

Icon FLEX   FLEXcyte 96 data and applications:
Cells were kindly provided by NEXEL.

Digoxin concentration response curves, mean IC50 calculation (n=40). A reduction of beating amplitude in a concentration dependent manner can be observed, concentrations > 1 µM predominately promote cytotoxic effects.

 

Cardiac Action Potentials - Detection of cardiac arrhythmia

FLEXcyte Arrhythmia data

Icon FLEX   FLEXcyte 96 data and applications:
Cells were kindly provided by NEXEL.

Contractile behavior of NEXEL cells. DataControl software allows an overview on mean beats including standard deviations from all 96-wells. Thus, arrhythmia or rhythmic beating can be judged at a glance.

 

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