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2022 - Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

icon sp96  SyncroPatch 768 PE (a predecessor model of the SyncroPatch 384 instrument) publication in Nature Genetics (2022)

Barc J., Tadros R., Glinge C., Chiang D.Y., Jouni M., Simonet F., Jurgens S.J., Baudic M., Nicastro M., Potet F., Offerhaus J.A., Walsh R., Choi S.H., Verkerk A.O., Mizusawa Y., Anys S., Minois D., Arnaud M., Duchateau J., Wijeyeratne Y.D., Muir A., Papadakis M., Castelletti S., Torchio M., Ortuño C.G., Lacunza J., Giachino D.F., Cerrato N., Martins R.P., Campuzano O., Van Dooren S., Thollet A., Kyndt F., Mazzanti A., Clémenty N., Bisson A., Corveleyn A., Stallmeyer B., Dittmann S., Saenen J., Noël A., Honarbakhsh S., Rudic B., Marzak H., Rowe M.K., Federspiel C., Le Page S., Placide L., Milhem A., Barajas-Martinez H., Beckmann BM., Krapels I.P., Steinfurt J., Winkel B.G., Jabbari R., Shoemaker M.B., Boukens B.J., Škorić-Milosavljević D., Bikker H., Manevy F.C., Lichtner P., Ribasés M., Meitinger T., Müller-Nurasyid M., KORA-Study Group, Veldink J.H., van den Berg L.H., Van Damme P., Cusi D., Lanzani C., Rigade S., Charpentier E., Baron E., Bonnaud S., Lecointe S., Donnart A., Le Marec H., Chatel S., Karakachoff M., Bézieau S., London B., Tfelt-Hansen J., Roden D., Odening K.E., Cerrone M., Chinitz L.A., Volders P.G., van de Berg M.P., Laurent G., Faivre L., Antzelevitch C., Kääb S., Arnaout A.A., Dupuis JM., Pasquie JL., Billon O., Roberts J.D, Jesel L., Borggrefe M., Lambiase P.D., Mansourati J., Loeys B., Leenhardt A., Guicheney P., Maury P., Schulze-Bahr E., Robyns T., Breckpot J., Babuty D., Priori S.G., Napolitano C., Nantes Referral Center for inherited cardiac arrhythmia, de Asmundis C., Brugada P., Brugada R., Arbelo E., Brugada J., Mabo P., Behar N., Giustetto C., Molina M.S., Gimeno J.R., Hasdemir C., Schwartz P.J., Crotti L., McKeown P.P, Sharma S., Behr E.R., Haissaguerre M., Sacher F., Rooryck C., Tan H.L., Remme C.A., Postema P.G., Delmar M., Ellinor P.T., Lubitz S.A., Gourraud JB., Tanck M.W., George Jr. A.L, MacRae C.A., Burridge P.W., Dina C., Probst V., Wilde A.A., Schott JJ, Redon R., & Bezzina C.R.


Nature Genetics (2022) doi: 10.1038/s41588-021-01007-6


Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1.5, susceptibility genes remain largely unknown. Here we performed a genome-wide association meta-analysis comprising 2,820 unrelated cases with BrS and 10,001 controls, and identified 21 association signals at 12 loci (10 new). Single nucleotide polymorphism (SNP)-heritability estimates indicate a strong polygenic influence. Polygenic risk score analyses based on the 21 susceptibility variants demonstrate varying cumulative contribution of common risk alleles among different patient subgroups, as well as genetic associations with cardiac electrical traits and disorders in the general population. The predominance of cardiac transcription factor loci indicates that transcriptional regulation is a key feature of BrS pathogenesis. Furthermore, functional studies conducted on MAPRE2, encoding the microtubule plus-end binding protein EB2, point to microtubule-related trafficking effects on NaV1.5 expression as a new underlying molecular mechanism. Taken together, these findings broaden our understanding of the genetic architecture of BrS and provide new insights into its molecular underpinnings.

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