Nanion Corporate Blog

 

17.08.2020: Free Application Note - Secondary screening assay for amino acid transporter inhibitors

Secondary screening assay for amino acid transporter inhibitors on the SURFE2R 96SE

Summary:

Na-dependent amino acid transporters play an essential role in the uphill transport of amino acids across the plasma membrane. In this study, a novel transporter target was used for which few specific pharmacological tools are available. The aim of this study was to establish a secondary screening assay using the direct electrophysiological measurement of the transporter to identify inhibitors. Using the SURFE2R 96SE, substrate specificity was determined and inhibitors could be identified. 

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