Nanion Corporate Blog


13.11.2020 - A deep-dive into ClC: Chloride/Proton Exchanger

ClC - Chloride/Proton Exchanger


The Chloride Carrier/Channel Family is a large but poorly understood family consisting of several hundred sequenced proteins from bacteria and eucaryotes. Although structurally similar, the individual proteins act either as chloride channels or as chloride/proton exchangers. Most CIC proteins are located in the plasma membrane, but several are predominantly in intracellular membranes.

Click here to read more about ClC and enjoy access to additional Publications

Application Note:

Here we present Ec-ClC activity measurements on the SURFE2R N1 instrument using proteoliposomes reconstituted with purified Ec-ClC at different lipid-to-protein ratios:

Download the Free Application Note - Electrophysiological recordings of the H+/Cl- exchanger Ec-ClC

Watch this On-Demand Presentation to learn how Dr. Matthias Quick is using SURFE2R Technology to investigate Membrane Transporters:


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