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30.11.2020: Publication Alert - The two‐pore domain K2P channel TASK2 drives human NK‐cell proliferation and cytolytic function

The two‐pore domain K2P channel TASK2 drives human NK‐cell proliferation and cytolytic function

Abstract

Human respiratory syncytial virus (HRSV) is a common cause of respiratory tract infections (RTIs) globally and is one of the most fatal infectious diseases for infants in developing countries. Of those infected, 25%–40% aged ≤1 year develop severe lower RTIs leading to pneumonia and bronchiolitis, with ~10% requiring hospitalisation. Evidence also suggests that HRSV infection early in life is a major cause of adult asthma. There is no HRSV vaccine, and the only clinically approved treatment is immunoprophylaxis that is expensive and only moderately effective. New anti-HRSV therapeutic strategies are therefore urgently required.

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