Nanion Corporate Blog


16.12.2020 - A deep-dive into ASIC3

ASIC3 - Acid-Sensing Ion Channel 3

Acid-sensing ion channels, member of the ENaC/Degenerin superfamily

Members and topology:
The channels are encoded by five genes: ASIC1 - ASIC5. ASIC1a,  ASIC1b, ASIC2a, ASIC2b are splice variants. Each subunit has 2 transmembrane domains flanking a large extracellular loop with short intracellular N and C termini. Three of these protein subunits assemble to form the ASIC ion channel, which can combine into both homotrimeric and heterotrimeric channels.

Regulation and function:
Neuronal voltage-insensitive cationic channels activated by extracellular protons. ASICs are Na+ permeable with ASIC1a showing low Ca2+ permeability. The role of the ASIC is to sense reduced levels of extracellular pH and result in a response or signal from the neuron.

Click here to read more about ASIC3 and enjoy access to additional Publications and Application Notes

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