Nanion Corporate Blog

 

27.12.2021 - 2022 Scientists’ Choice Awards

2022 SelectScience Scientists' Choice Awards® 

Best New Drug Discovery & Development Product of 2021! Laboratory scientists across the world are being invited to have their say in the 2022 Scientists’ Choice Awards®.

Now in their 15th year, the annual Scientists' Choice Awards® celebrate the most innovative and effective technologies of the past year and provide scientists worldwide with the opportunity to acknowledge the instruments, assays, tools or consumables that have made the highest impact to their work.

We are delighted to announce that the SyncroPatch 384 has been nominated this year in the following category: Best New Drug Discovery & Development Product of 2021!

From biophysical characterization of Nobel Prize winning ion channels important in touch and temperature sensation, to routine safety testing of cardiac ion channels, the SyncroPatch 384 can do it all due to its high flexibility.

Voting is now open, so if you’re happy with how this product has helped with your work, please take a moment to give us your support – we would be very grateful.

Cast your vote here

As a thank you for your time and insight, you’ll be entered into a prize drawing for the chance to win a $500 Amazon.com Gift Card* provided by SelectScience.

We want as many scientists as possible to have their say, so please forward this email to colleagues, students or friends who may also be interested.
Voting closes on January 24, 2022.

The winner will be announced at SLAS 2022, which will take place in Boston, Massachusetts on February 5 - 9, 2022.

See the Scientists’ Choice Awards website for details.


SyncroPatch 384 - Downloads                                                                                                                               

Application Notes

AMPA receptor (GluA2) - "Activation, potentiation and inhibition of AMPA receptors on the SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) application note:   logo pdf   (3.1 MB)
Cells were kindly provided by SB Drug Discovery.

ASIC3 - "Activation and Inhibition of human ASIC3 Channels on Nanion’s SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) application note:   logo pdf   (2.2 MB)
Cells were kindly provided by Millipore.  

Assay Ready TRP-Channel Expressing Cells - a Flexible Tool to Screen for New Drug Candidates

icon sp96   SyncroPatch 384i (a predecessor model of SyncroPatch 384) application note:   logo pdf   (1.0 MB)
Patch Ready Cells provided by acCELLerate

Cardiac Ion Channels - "High Throughput Screening of Cardiac Ion Channels"

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384)   icon pl   Patchliner   Icon CE   CardioExcyte 96 application note   logo pdf   (2.3 MB)

Cardiac Ion Channels - "Simultaneous Assessment of CiPA Stipulated Ion Channels on the SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) application note   logo pdf   (1.3 MB)
Cells were kindly provided by Charles River.

Cardiomyocytes - "Combining automated patch clamp, impedance and EFP of hiPSC-CMs"

Icon CE   CardioExcyte 96   icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384)   icon pl   Patchliner Application Note 
Cells kindly provided by Takara-Clonetech.

CaV1.2 - "High Throughput Pharmacology of CaV1.2 Channels on Nanion’s SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) application note:   logo pdf   (2.7 MB)
Cells were kindly provided by SB Drug Discovery.  

CaV1.2 - "Stability and Pharmacology of CaV1.2 Channels on Nanion’s SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) application note   logo pdf   (5.3 MB)
Cells were kidly provided by Charles River.

CaV1.2 - "Stable Recordings and High Throughput Pharmacology of Assay Ready CaV1.2 Cells on the SyncroPatch 384"

icon sp96   SyncroPatch 384 application note:   logo pdf   (1.6 MB)
Cells were kindly provided by NMI TT Pharmaservices, Steinbeis-Innovationszentrum Zellkulturtechnik and acCELLerate

CaV3.2 - "High Throughput Pharmacology of CaV3.2 Channels on Nanion’s SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) application note:   logo pdf   (0.6 MB)
Cells were kindly provided by Millipore.  

CFTR - "Different modes of activation of CFTR recorded on Nanion’s SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) application note   logo pdf   (5.7 MB)

hASIC1a - "Pharmacology of human ASIC1a channels on Nanion’s SyncroPatch 384i"

icon sp96   SyncroPatch 384i (a predecessor model of the SyncroPatch 384) application note:   logo pdf   (1.4 MB)
Cells were kindly provided by Charles River.

hClC-1 - "Characterization of hClC-1 on the SyncroPatch 384"

icon sp96   SyncroPatch 384 application note:   logo pdf   (1.6 MB)
Cells were kindly provided by Charles River

HCN2 receptor - "Biophysical modulation of hHCN2 by bPAC recorded on the SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) application note:   logo pdf   (1.0 MB)
Cells were engineered and kindly provided by Axxam S.p.A.

hERG - "High Throughput Pharmacology of hERG Channels on Nanion’s SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) application note   logo pdf   (0.6 MB)

hNaV1.9 - "High Throughput Pharmacology of NaV1.9 Channels on Nanion’s SyncroPatch 384"

icon sp96   SyncroPatch 384 application note:   logo pdf   (1.6 MB)
Cells kindly provided by Icagen, Inc., USA.

hTRPA1 - "Reproducible activation and pharmacology of hTRPA1 on the SyncroPatch 384"

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) application note:   logo pdf   (3.1 MB)
Cells were kindly provided by Charles River

nAChRα4β2 - "Pharmacology of human α4β2 nAChR recorded on the SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) application note:   logo pdf   (0.8 MB)
Cells were engineered and kindly provided by SB Drug Discovery.  

NaV1.5 - "High Throughput Pharmacology of NaV1.5 Channels on Nanion's SyncroPatch 384PE"

icon sp96   SyncroPatch 384i (a predecessor model of the SyncroPatch 384) application note   logo pdf   (1.5 MB)
Cells were kindly provided by Millipore.

NaV1.5 - "Increase throughput by recording in unattended mode on the SyncroPatch 384"

icon sp96   SyncroPatch 384PE and SyncroPatch 384i (a predecessor model of the SyncroPatch 384) application note:   logo pdf   (2.2 MB)
Cells were kindly provided by Charles River.  

NaV1.5 - "NaV1.5-ΔKPQ late INa current properties and pharmacology on the SyncroPatch 384i"

icon sp96   SyncroPatch 384i (a predecessor model of the SyncroPatch 384) application note   logo pdf (1.5 MB)
Cells were kindly provided by Metrion Biosciences.

NaV1.7 - "Characterization of hNaV1.7 on Nanion's SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) application note   logo pdf   (0.7 MB)
Cells were kindly provided by Anaxon.

NaV1.8 - "Stability and reproducibility of hNaV1.8 recordings on Nanion's SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) application note   logo pdf   (1.4 MB)
Cells were kindly provided by Charles River.

Neurons - "Electrophysiological recordings of LGIC and AA transporters in iCell® GlutaNeurons"

icon pl   Patchliner,  icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) and   Icon N1   SURFE2R N1 application note:   logo pdf   (0.5 MB)
Cells were kindly provided by FUJIFILM Cellular Dynamics, Inc.  

NMDA Receptors (NR1/NR2B) - "Activation and Inhibition of human NMDA Channels on Nanion`s SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) application note   logo pdf   (1.7 MB)
Cells were kindly provided by Charles River.

P2X2 / P2X3 - "Pharmacology of P2X2/3 channels recorded on the SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) application note:   logo pdf   (5 MB)
Cells were engineered and kindly provided by Axxam S.p.A., Milan.  

P2X3 - "Activation and inhibition of P2X3 channels recorded on the SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) application note:   logo pdf   (1.5 MB)
Cells were engineered and kindly provided by Axxam S.p.A., Milan.  

Qualification of Patch Ready Cells on a SyncroPatch 384PE

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) application note:   logo pdf   (1.0 MB)
Patch Ready Cells provided by acCELLerate

Reproducible activation and pharmacology of α1β1γδ nAChR on the SyncroPatch 384

icon sp96   SyncroPatch 384 application note:   logo pdf   (3.4 MB)
Cells were kindly provided by CLS

TASK-1 - "Activation and Inhibition of TASK-1 on Nanion’s SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) application note:   logo pdf   (3.1 MB)
Cells were kindly provided by SB Drug Discovery.

TMEM16A (ANO1) - "Internal perfusion of Ca2+ to activate TMEM16A/ANO1 on the SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) application note   logo pdf   (1.1 MB)
Cells were kindly provided by SB Drug Discovery.

TREK-1 - "Activation and inhibition of TREK-1 on Nanion’s SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) application note   logo pdf   (6.0 MB)
Cells were kindly provided by SB Drug Discovery.

TRPA1 - "High Throughput Activation and Block of hTRPA1 on Nanion’s SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) application note   logo pdf   (0.6 MB)
Cells were kindly provided by Millipore.

TRPC5 - "Internal perfusion of Ca2+ to activate hTRPC5 on Nanion's SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) application note   logo pdf   (1.7 MB)
Cells were kindly provided by Charles River.

Publications

2022 - Altered Ca2+ Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis

icon sp96 SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) Publication in Cells (2022)

Authors:
Buks R., Dagher T., Rotordam M. G., Alonso D. M., Cochet S., Gautier E-F., Chafey P., Cassinat B., Kiladjian J-J., Becker N., Plo I., Egée S., Nemer W. E.

2021 - The suitability of high throughput automated patch clamp for physiological applications

icon sp96  SyncroPatch 384 Publication in The Journal of Physiology (2021)

Authors:
Obergrussberger A., Rinke-Weiß I., Goetze T.A., Rapedius M., Brinkwirth N., Becker N., Rotordam M.G., Hutchison L., Madau P, Pau D, Dalrymple D., Braun N., Friis S., Pless S.A., Fertig N.

2021 - The Schizophrenia Variant V1282F in SCN2A Causes Functional Impairment of NaV1.2

icon sp96 SyncroPatch Publication in Journal of Schizophrenia Research (2021)

Authors:
Kohlnhofer B., Liu Y., Woodruff G., Lovenberg T., Kohlnhofer B., Liu Y., Woodruff G., Bonaventure P., and Harrington AW.

2021 - The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs

icon sp96 SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) Publication in Journal of General Physiology (2021)

Authors:
Sheikh Z.P. , Wulf M., Friis S., Althaus M., Lynagh T., Pless S.A.

2021 - The insecticide deltamethrin enhances sodium channel slow inactivation of human Nav1.9, Nav1.8 and Nav1.7

icon sp96  SyncroPatch 384i (a predecessor model of the SyncroPatch 384) Publication in Toxicology and Applied Pharmacology (2021)

Authors:
Bothe S.N., Lampert A.

2021 - Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM

icon sp96  SyncroPatch 384 Publication in Nature Communications (2021)

Authors:
Raisch T., Brockmann A., Ebbinghaus-Kintscher U., Freigang J., Gutbrod O., Kubicek J., Maertens B., Hofnagel O., Raunser S.

2021 - Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment

icon sp96  SyncroPatch 384 and   icon pl   Patchliner Publication in Journal of Pharmacological and Toxicological Methods (2021)

Authors:
Rotordam M.G., Obergrussberger A., Brinkwirth N., Takasuna K., Becker N., Horvátha A., Goetze T.A., Rapedius M., Furukawa H., Hasegawa Y., Oka T., Fertig N., Stoelzle-Feix S

2021 - Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome

icon sp96 SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) publication in Biological Psychiatry (2021)

Authors:
Hwang H., Szucs M.J., Ding L.J., Allen A., Ren X., Haensgen H., Gao F., Rhim H., Andrade A., Pan J.Q., Carr S.A., Ahmad R., Xu W.

2021 - Neuroactive Type-A γ-Aminobutyric Acid Receptor Allosteric Modulator Steroids from the Hypobranchial Gland of Marine Mollusk, Conus geographus

icon sp96  SyncroPatch 384i (a predecessor model of the SyncroPatch 384) Publication in Journal of Medicinal Chemistry (2021)

Authors:
Niu C., Leavitt L. S., Lin Z., Paguigan N. D., Sun L., Zhang J., Torres J. P., Raghuraman S., Chase K., Cadeddu R., Karthikeyan M., Bortolato M., Reilly C. A., Hughen R. W., Light A. R., Olivera B. M., Schmidt E. W.

2021 - Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) publication in BMC Molecular and Cell Biology (2021)

Authors:
Matsumura K., Shimomura T., Kubo Y., Oka T., Kobayashi N., Imai S., Yanase N., Akimoto M., Fukuda M., Yokogawa M., Ikeda K., Kurita J., Nishimura Y., Shimada I., Osawa M.

2021 - Machine Learning Strategies When Transitioning between Biological Assays

icon sp96 SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) publication in Journal of Chemical Infromation and Modeling (2021)

Authors:
McShane S. A., Ahlberg E., Noeske T., Spjuth O.

2021 - Induced Pluripotent Stem Cell-Derived Cardiomyocytes with SCN5A R1623Q Mutation Associated with Severe Long QT Syndrome in Fetuses and Neonates Recapitulates Pathophysiological Phenotypes

icon sp96 SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) Publication in Biology (2021)

Authors:
Hayama E., Furutani Y., Kawaguchi N., Seki A., Nagashima Y., Okita K., Takeuchi D., Matsuoka R., Inai K., Hagiwara N., Nakanishi T.

2021 - Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay

icon sp96  SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) Publication in SLAS Discovery (2021)

Authors:
Virginio C., Aldegheri L., Nola S., Brodbeck D., Brault L., Raveglia L. F., Barilli A., Sabat M., Myers R.

2021 - High-Throughput Screening of TRPV1 Ligands in the Light of the Bioluminescence Resonance Energy Transfer Technique

icon sp96  SyncroPatch 384 Publication in Molecular Pharmacology (2021)

Authors:
Chappe Y., Michel P., Joushomme A., Barbeau S., Pierredon S., Baron L., Garenne A., Poulletier De Gannes F., Hurtier A., Mayer S., Lagroye I., Quignard J-F., Ducret T., Compan V., Franchet C., Percherancier Y.

2021 - High-throughput Evaluation of Epilepsy-associated KCNQ2 Variants Reveals Functional and Pharmacological Heterogeneity

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 384 instrument) Publication in bioRxiv (2021)

Authors:
Vanoye C.G., Desai R. R., Ji Z., Adusumilli S., Jairam N., Ghabra N., Joshi N., Fitch E., Helbig K., McKnight D., Lindy A., Zou F., Helbig I., Cooper E., George Jr. A.L.

2021 - High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology

icon pl   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) Publication in PLoS Biology (2021)

Authors:
Braun N., Friis S., Ihling C., Sinz A., Andersen J., Pless S.A.

2021 - Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology

icon sp96  SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) Publication in Biol. Methods Protoc. (2021)

Authors:
Ng C-A., Farr J., Young P., Windley M.J., Perry M.D., Hill A.P., Vandenberg J.I.

2021 - From High-Throughput Screening to Target Validation: Benzo[d]isothiazoles as Potent and Selective Agonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 5 Possessing In Vivo Gastrointestinal Prokinetic Activity in Rodents

icon sp96 SyncroPatch 384 Publication in Journal of Medicinal Chemistry (2021)

Authors:
Barilli A., Aldegheri L., Bianchi F., Brault L., Brodbeck D., Castelletti L., Feriani A., Lingard I., Myers R., Nola S., Piccoli L., Pompilio D.,Raveglia L.F., Salvagno C., Tassini S., Virginio C., Sabat M.

2021 - Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model

icon sp96  SyncroPatch 384 Publication in Journal of Medicinal Chemistry (2021)

Authors:
De Fusco C., Schimpl M., Börjesson U., Cheung T., Collie I., Evans L., Narasimhan P., Stubbs C., Vazquez-Chantada M., Wagner D. J., Grondine M., Sanders M. G., Tentarelli S., Underwood E., Argyrou A., Smith J. M., Lynch J. T., Chiarparin E., Robb G., Bagal S. K., Scott J. S.

2021 - Fluorescent- and tagged-protoxin II peptides: potent markers of the Nav1.7 channel pain target

icon sp96SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) Publication in British Journal of Pharmacological (2021)

Authors:
Montnach J., De Waard S., Nicolas S., Burel S., Osorio N., Zoukimian C., Mantegazza M., Boukaiba R., Béroud R., Partiseti M., Delmas P., Marionneau C., De Waard M.

2021 - Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

icon sp96  SyncroPatch 768 PE (a predecessor model of the SyncroPatch 384 instrument) publication in Nature (2021)

Authors:
Simkin D., Marshall K.A., Vanoye C.G., Desai R.R., Bustos B.I., Piyevsky B.N., Ortega J.A., Forrest M., Robertson G.L., Penzes P., Laux L.C., Lubbe S.J., Millichap J.J., George Jr A.L., Kiskinis E.

2021 - Dominant negative effects of SCN5A missense variants

icon sp96 SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) pre-print publication in bioRxiv (2021)

Authors:
O’Neill M. J., Muhammad A., Li B., Wada Y., Hall L., Solus J. F., Short L., Roden D. M., Glazer A. M.

2021 - Disease-linked super-trafficking of a potassium channel

icon sp96  SyncroPatch 768 PE (a predecessor model of the SyncroPatch 384 instrument) publication in Journal of Biological Chemistry (2021)

Authors:
Huang H.,Chamness L.M., Vanoye C.G., Kuenze G., Meiler J., George A.L., Schlebach J.P., Sanders C.R.

2021 - Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series

icon sp96  SyncroPatch 384 Publication in ACS Medicinal Chemistry Letters (2021)

Authors:
Griffin A. M., Kahlig K. M., Hatch R. J., Hughes Z. A., Chapman M. L., Antonio B., Marron B. E., Wittmann M., Martinez-Botella G.

2021 - Computer modeling of whole-cell voltage-clamp analyses to delineate guidelines for good practice of manual and automated patch-clamp

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) Publication in Scientific Reports (2021)

Authors:
Montnach J., Lorenzini M., Lesage A., Simon I., Nicolas S., Moreau E., Marionneau C., Baró I., De Waard M., Loussouar G.

2021 - Comprehensive preclinical evaluation of how cardiac safety profiles of potential COVID-19 drugs are modified by disease associated factors

icon sp96  SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) prepublication in Authorea (2021)

Authors:
TeBay C., McArthur J., Mangala M., Kerr N., Heitmann S., Perry M., Windley M., Vandenberg J., Hill A.

2021 - Chemical modulation of Kv7 potassium channels

icon sp96  SyncroPatch 384 Publication in RSC Medicinal Chemistry (2021)

Authors:
Borgini M., Mondal P., Liu R., Wipf P.

2021 - Characterization of Vixotrigine, a Broad-Spectrum Voltage-Gated Sodium Channel Blocker

icon sp96  SyncroPatch 384PE  (a predecessor model of the SyncroPatch 384 instrument) Publication in Molecular Pharmacology (2021)

Authors:
A. Hinckley C., Kuryshev Y., Sers A., Barre A., Buisson B., Naik H., Hajos M.

2021 - Cation and anion channelrhodopsins: Sequence motifs and taxonomic distribution

icon sp96  SyncroPatch 384i (a predecessor model of the SyncroPatch 384) Pre-Publication in bioRxiv (2021)

Authors:
Govorunova E.G., Sineshchekov O.A., Li H., Wang Y., Brown L.S., Palmateer A., Melkonian M., Cheng S., Carpenter E., Patterson J., Wong G. K-S., Spudich J.L.

2021 - Cardiovascular and Respiratory Toxicity of Protamine Sulfate in Zebrafish and Rodent Models

icon sp96  SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) Publication in Pharmaceutics (2021)

Authors:
Miklosz J., Kalaska B., Podlasz P., Chmielewska-Krzesińska M., Zajączkowski M., Kosiński A., Pawlak D., Mogielnicki A.

2021 - Arrhythmia variant associations and reclassifications in the eMERGE-III sequencing study

icon sp96  SyncroPatch 768 PE (a predecessor model of the SyncroPatch 384 instrument) pre-print publication in MedRxiv (2021)

Authors:
Glazer A. M., Davogustto G., Shaffer C. M.,Vanoye C. G., Desai R. R., Farber-Eger E. H., Dikilitas O., Shang N., Pacheco J. A., Yang T., Muhammad A., Mosley J. D., Van Driest S. L., Wells Q. S., Rinke L. L., Kalash O. R., Wada Y., Bland S., Yoneda Z. T., Mitchell D. W., Kroncke B. M., Kullo I. J., Jarvik G. P., Gordon A. S., Larson E. B., Manolio T. A., Mirshahi T., Luo J. Z.,Schaid D., Namjou B., Alsaied T., Singh R., Singhal A., Liu C., Wenig C., Hripcsak G., Ralston J. D., McNally E. M., Chung W. K., Carrell D. S., Leppig K. A., Hakonarson H., Sleiman P., Sohn S., Glessner J., the eMERGE Network, Denny J., Wie W-Q., Jr. George A. L., Shoemaker M. B., Roden D. M.

2021 - Applying the CiPA Approach to Evaluate Cardiac Proarrhythmia Risk of some Antimalarials Used Off‐label in the First Wave of COVID‐19

icon sp96  SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) prepublication in Clinical and Translational Science (2021)

Authors:
Delaunois A., Abernathy M., Anderson W.D., Beattie K.A., Chaudhary K.W., Coulot J., Gryshkova V., Hebeisen S., Holbrook M., Kramer J., Kuryshev Y., Leishman D., Lushbough I., Passini E., Redfern W.S., Rodriguez B., Rossman E.I., Trovato C., Wu C., Valentin J-P.

2021 - Analysing an allelic series of rare missense variants of CACNA1I in a Swedish schizophrenia cohort

icon sp96 SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) Publication in Brain: A Journal of Neurology (2021)

Authors:
Baez-Nieto D., Allen A., Akers-Campbell S., Yang L., Budnik N., Pupo A., Shin Y-C., Genovese G., Liao M., Pérez-Palma E., Heyne H., Lal D., Lipscombe D., Pan J.Q.

2021 - An Efficient and Scalable Data Analysis Solution for Automated Electrophysiology Platforms

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 384 instrument) Publication in SLAS Discovery (2021)

Authors:
Li T., Ginkel M.,Yee A.X., Foster L., Chen J., Heyse S., Steigele S.

2021 - A Massively Parallel Trafficking Assay Accurately Predicts Loss of Channel Function in KCNH2 Variants

icon sp96 SyncroPatch 384PE (a predecessor to the SyncroPatch 384 model) Publication in BioRxiv (2021)

Authors:
Ng C-H. Ullah R. Farr J. Hill A.P, Kozek K.A., Vanags L.R. Mitchell D. Kroncke B.M., Vandenberg J.I.

2021 - 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents

icon sp96  SyncroPatch 384 Publication in The Journal of Medicinal Chemistry (2021)

Authors:
Konno S., Kobayashi K., Senda M., Funai Y., Seki Y., Tamai I., Schäkel L., Sakata K., Pillaiyar T., Taguchi A., Taniguchi A., Gütschow M., Müller C. E., Takeuchi K., Hirohama M., Kawaguchi A., Kojima M., Senda T., Shirasaka Y., Kamitani W., Hayashi Y.

2020 - VU0606170, a Selective Slack Channels Inhibitor, Decreases Calcium Oscillations in Cultured Cortical Neurons

icon sp96  SyncroPatch 768 PE (a predecessor model of the SyncroPatch 384 instrument) publication in ACS Chemical Neuroscience (2020)

Authors:
Spitznagel B.D., Mishra N.M., Qunies A.M., Prael F.J., Du Y., Kozek K.A., Lazarenko R.M., Denton J.S., Emmitte K.A., Weaver C.D.

2020 - Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk

 icon sp96 SyncroPatch 384 (a predecessor model of the SyncroPatch 768i instrument) publication in Cell Stem Medicine (2020)

Authors:
Davies M.R., Martinec M., Walls R., Schwarz R., Mirams G.R., Wang K., Steiner G., Surinach A., Flores C., Lave T., Singer T., Polonchuk L.

2020 - Trends in the Development of Diagnostic Tools for Red Blood Cell-Related Diseases and Anemias

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument) publication in Frontiers in Physiology (2020)

Authors:
Kaestner L., Bianchi P.

2020 - Striatal Kir2 K+ channel inhibition mediates the antidyskinetic effects of amantadine

 icon sp96   SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i instrument) publication in The Journal of Clinical Investigation (2020)

Authors:
Shen W., Ren W., Zhai S., Yang B., Vanoye C.G., Mitra A., George AL. Jr., Surmeier D.J.

2020 - Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment

icon pl   Patchliner and   icon sp96   SyncroPatch 384i (SyncroPatch 384PE a predecessor model) publication in the Journal of Pharmacological and Toxicological Methods (2020)

Authors:
Brinkwirth N., Takasuna K., Masafumi D., Becker N., Obergrussberger A., Friis S., Furukawa Y., Hasegawa Y., Oka T., Ohtsuki A., Fertig N., Stoelzle-Feix S.

2020 - Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity

icon pl Patchliner and  icon sp96 SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i instrument) publication in Cell Stem Cell (2020)

Authors:
McKeithan W. L., Feyen D.A.M., Bruyneel A.A.N., Okolotowicz K.J., Ryan D.A., Sampson K.J., Potet F., Savchenko A., Gómez-Galeno J., Vu M., Serrano R., George Jr. A.L., Kass R.S., Cashman J.R., Mercola M.

2020 - Predicting Functional Effects of Missense Variants in Voltage-Gated Sodium and Calcium

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) Publication in Science Translational Medicine (2020)

Authors:
Heyne H.O., Baez-Nieto D., Iqbal S., Palmer D., Brunklaus A., Johannesen K.M., Lauxmann S., Lemke J.R., Møller R.S., Pérez-Palma E., Scholl U., Syrbe S., Lerche H., May P., Lal D., Campbell A.J., Pan J., Wang H.-R., Daly M.J.

2020 - Novel Expression of GABAA Receptors on Resistance Arteries That Modulate Myogenic Tone

icon sp96   SyncroPatch 96 (a predecessor model of the SyncroPatch 384i) Publication in Journal of Vascular Research (2020)

Authors:
Yim P.D., Gallos G., Lee-Kong S.A., Dan W., Wu A.D., Xu D., Berkowitz D.E., Emala C.W.

2020 - Mechanism and site of action of big dynorphin on ASIC1a

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) Publication in PNAS (2020)

Authors:
Borg C.B., Braun N., Heusser S.A., Bay Y., Weis D., Galleano I., Lund C., Tian W., Haugaard-Kedström L.M., Bennett E.P., Lynagh T., Strømgaard K., Andersen J., Pless S.A.

2020 - Ion Channels and Relevant Drug Screening Approaches

icon sp96   SyncroPatch 384i editorial found in SLAS Discovery (2020)

Authors:
McGivern, J.G., Ding M.

2020 - High-throughput reclassification of SCN5A variants

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) Publication in The American Journal of Human Genetics (2020)

Authors:
Glazer A.M., Wada Y., Li B., Muhammad A., Kalash O.R., O’Neill M.J., Shields T., Hall L., Short L., Blair M.A., Kroncke B.M., Capra J.A., Roden D.M

2020 - High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KCNH2: Deep mutational scan of KCNH2 trafficking

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument) Pre-publication in bioRxiv Biology (2020)

Authors:
Kozek K.A., Glazer A.M., Ng C.-A., Blackwell D., Egly C.L., Vanags L.R., Blair M., Mitchell D., Matreyek K.A., Fowler D.M., Knollmann B.C., Vandenberg J., Roden D.M., Kroncke B.M.

2020 - GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-derived Cardiomyocytes

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i) pre-publication in bioRxiv (2020)

Authors:
Potet F., Egecioglu D.E., Burridge P.W.,George A.L. Jr.

2020 - Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i instrument) publication in Medicinal Chemistry (2020)

Authors:
Scott J.S., Moss T.A., Balazs A., Barlaam B., Breed J., Carbajo R.J., Chiarparin E., Davey P.R.J., Delpuech O., Fawell S., Fisher D.I., Gagrica S., Gangl E.T., Grebe T., Greenwood R.D., Hande S., Hatoum-Mokdad H., Herlihy K., Hughes S., Hunt T.A., Huynh H., Janbon S.L.M., Johnson T., Kavanagh S., Klinowska T., Lawson M., Lister A.S., Marden S., McGinnity D.F., Morrow C.J., Nissink W.M., O'Donovan D.H., Peng B., Polanski R., Stead D.S., Stokes S., Thakur K., Throner S.R., Tucker M.J., Varnes J., Wang H., Wilson D.M., Wu D., Wu Y., Yang B., Yang W.

2020 - Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

icon pl   Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument) publication in Nature Scientific Reports (2020)

Authors:
Kramer J., Himmel H.M., Lindqvist A., Stoelzle-Feix S., Chaudhary K.W., Li D., Bohme G.A., Bridgland-Taylor M., Hebeisen S., Fan J., Renganathan M., Imredy J., Humphries E.S.A, Brinkwirth N., Strassmaier T., Ohtsuki A., Danker T., Vanoye C., Polonchuk L., Fermini B., Pierson J.B. & Gintant G.

2020 - Conservation and divergence in NaChBac and NaV1.7 pharmacology reveals novel drug interaction mechanisms

 icon sp96   SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i instrument) publication in Nature Scientific Reports (2020)

Authors:

Zhu W., Li T., Silva J. R., Chen J.

2020 - Automated Patch Clamp in Drug Discovery: major breakthroughs and innovation in the last decade

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument)   icon pl   Patchliner and   icon pap   Port-a-Patch publication in Expert Opinion on Drug Discovery (2020)

Authors:
Obergrussberger A., Friis S., Brüggemann A., Fertig N.

2020 - Application of High-Throughput Automated Patch-Clamp Electrophysiology to Study Voltage-Gated Ion Channel Function in Primary Cortical Cultures

 icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in SLAS Discovery (2020)

Authors:
Toh M.F., Brooks J.M., Strassmaier T., Haedo R.J., Puryear C.B., Roth B.L., Ouk K., Pin S.S.

2020 - Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation

icon sp96  Syncropatch 768 PE publication in eLife (2020)

Authors:

Kuenze G., Vanoye C.G., Desai R.R., Adusumili S., Brewer K.R., Woods H., McDonald E.F., Sanders C.R., George Jr. A.L.

2020 - Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) publication in Philosophical Transactions of the Royal Society A (2020)

Authors:
Lei, C.L., Clerx, M., Whittaker, D.G., Gavaghan, D.J., de Boer, T.P., Mirams, G.R.

2020 - A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm

icon pl   Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument) publication in Toxicology and Applied Pharmacology (2020)

Authors:
Ridder B.J., Leishman D.J., Bridgland-Taylor M., Samieegohar M., Han X, Wu W.W., Randolph A., Tran P., Sheng J., Danker T., Lindqvist A., Konrad D., Hebeisen S., Polonchuk L., Gissinger E., Renganathan M., Koci B., Wei H., Fan J., Levesque P., Kwagh J., Imredy J., Zhai J., Rogers M., Humphries E., Kirby R., Stoelzle-Feix S., Brinkwirth N., Rotordam M.G., Becker N., Friis S., Rapedius M., Goetze T.A., Strassmaier T., Okeyo G., Kramer J., Kuryshev Y., Wu C., Himmel H., Mirams G.R., Strauss D.G., Bardenet R., Li Z.

2020 - A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model

 icon sp96   SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i instrument) publication in the Journal of Pharmacological and Toxicological Methods (2020)

Authors:

Han X., Samieegohar M., Ridder B.J., Wu W.W., Randolph A., Tran P., Sheng J., Stoelzle-Feiz S., Brinkwirth N., Rotordam M.G., Becker N., Friis S., Rapedius M., Goteze T.A., Strassmaier T., Okeyo G., Kramer J., Kuryshev Y., Li Z.

2019 - Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Bioorganic & Medicinal Chemistry (2019)

Authors:
Zoukimian C., Meudal H., De Waard S., Ait Quares K., Nicolas S., Canepari M., Béroud R., Landon C., De Waard M., Boturyn D.

2019 - Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Journal of Medicinal Chemistry (2019)

Authors:
McKerrall S.J., Nguyen T., Lai K.W., Bergeron P., Deng L., DiPasquale A., Chang J.H., Chen J., Chernov-Rogan T., Hackos D.H., Maher J., Ortwine D.F., Pang J., Payandeh J., Proctor W.R., Shields S.D., Vogt J., Ji P., Liu W., Ballini E., Schumann L., Tarozzo G., Bankar G., Chowdhury S., Hasan A., Johnson J.P. Jr., Khakh K., Lin S., Cohen C.J., Dehnhardt C.M., Safina B.S., Sutherlin D.P.

2019 - Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Cell (2019)

Authors:
Xu H., Li T., Rohou A., Arthur C.P., Tzakoniati F., Wong E., Estevez A., Kugel C., Franke Y., Chen J., Ciferri C., Hackos D.H., Koth C.M., Payandeh J.

2019 - Spectrum of KV2.1 Dysfunction in KCNB1‐Associated Neurodevelopmental Disorders

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 384/768i) Publication Annals of Neurology (2019)

Authors: 
Kang, S.K., Vanoye, C.G., Misra, S.N., Echevarria, D.M., Calhoun, J.D., O’Connor, J.B., Fabre, K.L., McKnight, D., Demmer, L., Goldenberg, P., Grote, L.E., Thiffault, I., Saunders, C., Strauss, K.A., Torkamani, A., van der Smagt, J., van Gassen, K., Carson, R.P., Diaz, J., Leon, E., Jacher, J.E., Hannibal, M.C., Litwin, J., Friedman, N.R., Schreiber, A., Lynch, B., Poduri, A., Marsh, E.D., Goldberg, E.M., Millichap, J.J., George Jr., A.L., Kearney, J.A.

2019 - Role of High‐Throughput Electrophysiology in Drug Discovery

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i),   icon pl   Patchliner and   icon pap   Port-a-Patch review article in Current Protocols in Pharmacology (2019)

Authors:
Liu C., Li T., Chen J.

2019 - Rapid characterisation of hERG channel kinetics II: temperature dependence

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Biophysical Journal (2019)

Authors:
Lei C.L., Clerx M., Beattie K.A., Melgari D., Hancox J.C., Gavaghan D.J., Polonchuk L., Wang K., Mirams G.R.

2019 - Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Biophysical Journal (2019)

Authors:
Lei C.L., Clerx M., Beattie K.A., Gavaghan D.J., Polonchuk L., Mirams G.R., Wang K.

2019 - Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Cardiovascular Research (2019)

Authors:
Perry M.D., Ng C-A., Mangala M.M., Ng T.Y.M., Hines A.D., Liang W., Xu M.J.O., Hill A.P., Vandenberg J.I.

2019 - In vitro and in vivo characterization of a synthetic scorpion toxin AmmTx3, a potent inhibitor of cardiac voltage-gated potassium channel Kv4.2

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) publication in Archives of Cardiovascular Diseases Supplements (2019)

Authors:
Nicolas S., Zoukimian C.,Meuda H., De Waard S., Ait Ouares K., Canepari M., Beroud R., Landon C., De Waard M., Boturyn D.

2019 - High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Heart Rhythm (2019)

Authors:
Ng C-A., Perry M.D., Liang W., Smith N.J., Foo B., Shrier A., Lukacs G.L., Hill A.P., Vandenberg J.I.

2019 - High Throughput Characterization of KCNB1 Variants Associated with Developmental and Epileptic Encephalopathy

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 384/768i) Pre-publication in bioRxiv (2019)

Authors: 
Kang, S.K., Vanoye, C.G., Misra, S.N., Echevarria, D.M., Calhoun, J.D., O’Connor, J.B., Fabre, K.L., McKnight, D., Demmer, L., Goldenberg, P., Grote, L.E., Thiffault, I., Saunders, C., Strauss, K.A., Torkamani, A., van der Smagt, J., van Gassen, K., Carson, R.P., Diaz, J., Leon, E., Jacher, J.E., Hannibal, M.C., Litwin, J., Friedman, N.R., Schreiber, A., Lynch, B., Poduri, A., Marsh, E.D., Goldberg, E.M., Millichap, J.J., George Jr., A.L., Kearney, J.A.

2019 - Functional consequences of a KCNT1 variant associated with status dystonicus and early‐onset infantile encephalopathy

icon sp96   SyncroPatch 384PE (a predeccessor model of the SyncroPatch 384i) publication in Annals of Clinical and Translational Neurology (2019)

Authors:
Gertler T.S., Thompson C.H., Vanoye C.G., Millichap J.J., George Jr A.L.

2019 - Electrophysiological evaluation of pentamidine and 17-AAG in human stem cell-derived cardiomyocytes for safety assessment

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) article in European Journal of Pharmacology (2019)

Authors:
Asahi Y., Nomura F., Abe Y., Doi M., Sakakura T., Takasuna K., Yasuda K.

2019 - Development of Photocrosslinking Probes Based on Huwentoxin-IV to Map the Site of Interaction on Nav1.7

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 384/768i) Publication in Cell Chemical Biology (2019)

Authors: 
Tzakoniati F., Xu H., Li T., Garcia N., Kugel C., Payandeh J., Koth C.M., Tate E.W.

2019 - Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) article in Bioorganic and Medicinal Chemistry Letters (2019)

Authors:
Sharma, S.H., Pablo J.L., Montesinos, M.S., Greka, A., Hopkins, C.R.

2019 - Compounds commonly used in equine medicine inhibits the voltage-gated potassium channel Kv11.1

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Research in Veterinary Science (2019)

Authors:
Calloe K., Rognant, S., Friis S., Shaughnessy C., Klaerke D.A., Trachsel D.

2019 - Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1

icon sp96  SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) publication in Toxins (2019)

Authors: 
Nicolas S., Zoukimian C., Bosmans F., Montnach J., Diochot S., Cuypers E., De Waard S., Béroud R., Mebs D., Craik D., Boturyn D., Lazdunski M., Tytgat J., De Waard M.

2019 - Aptamer Efficacies for In Vitro and In Vivo Modulation of αC-Conotoxin PrXA Pharmacology

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Molecules (2019)

Authors:
Taiwe G.S., Montnach J., Nicolas S., De Waard S., Fiore E., Peyrin E., El-Aziz T.M.A., Amar M., Molgó J., Ronjat M., Servent D., Ravelet C., De Waard M.

2019 - A Novel Gain-Of-Function Mutation Of Piezo1 Is Functionally Affirmed In Red Blood Cells By High-Throughput Patch Clamp

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Haematologica (2019)

Authors:
Rotordam G.M., Fermo E., Becker N., Barcellini W., Brüggemann A., Fertig N., Egée S., Rapedius M., Bianchi P., Kaestner L.

2018 - Towards Novel Bioactive Antiperspirants for Cosmetic Applications

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in IFSCC (2018)

Authors:
Ertongur-Fauth T., Fischer S., Hartmann D., Brüggemann A., Seeger V., Kleber A., Krohn M.

2018 - NaV Channels: Assaying Biosynthesis, Trafficking, Function

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) article in The Surfaceome (2018)

Authors:
Tomaselli G.F., Farinelli F.

2018 - Multifocal atrial and ventricular premature contractions with an increased risk of dilated cardiomyopathy caused by a Nav1.5 gain-of-function mutation (G213D)

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) -related publication in International Journal of Cardiology (2018)

Authors:
Calloe K., Broendberg A.K., Christensen A.H., Pedersen L.N., Olesen M.S., de los Angeles Tejada M., Friis S., Thomsen M.B., Bundgaard H., Jensen H.K.

2018 - Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 384/768i) publication in PNAS

Authors: 
Chernov-Rogan T., Li T., Lu G., Verschoof H., Khakh K., Jones S.W., Beresini M.H., Liu C., Ortwine D.F., McKerrall S.J., Hackos D.H., Sutherlin D., Cohen C.J., and Chen J.

2018 - High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) article in Circulation: Genomic and Precision Medicine (2018)

Authors:
Vanoye C.G., Desai R.R., Fabre K.L., Gallagher S.L., Potet F., DeKeyser J.M., Macaya D., Meiler J, Sanders C.R, and George Jr. A.L.

2018 - Developing High-Throughput Assays to Analyze and Screen Electrophysiological Phenotypes

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) book chapter in Phenotypic Screening (2018)

Authors:
Pan J.Q., Baez-Nieto D., Allen A., Wang HR., Cottrell J.R.

2018 - An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery

icon sp96   SyncroPatch 384/768PE (a predecessor model of SyncroPatch 384/768i) and   icon pl   Patchliner publication in Expert Opinion on Drug Discovery

Authors: 
Obergrussberger A., Goetze T.A., Brinkwirth N., Becker N., Friis S., Rapedius M., Haarmann C., Rinke-Weiß I., Stölzle-Feix S., Brüggemann A., George M., Fertig N.

2017 - Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

icon sp96  SyncroPatch 768PE (a predecessor model of SyncroPatch 384/768i) publication in Nature Communications (2017)

Authors: 
Chiang E.Y., Li T., Jeet S., Peng I., Zhang J., Lee W. P., DeVoss J., Caplazi P., Chen J., Warming S., Hackos D.H., Mukund S., Koth C.M., Grogan J.L.

2017 - High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE

icon sp96  SyncroPatch 768PE (a predecessor model of SyncroPatch 384/768i) publication in PLoS One (2017)

Authors: 
Li T, Lu G, Chiang E.Y., Chernov-Rogan T., Grogan J.L., Chen J.

2017 - Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy

icon sp96  SyncroPatch 768PE (a predecessor model of SyncroPatch 384/768i) publication in Neurology Genetics (2017)

Authors: 
Calhoun, J.D., Vanoye, C.G., Kok, F., George, A.L., Kearney, J.A.

2017 - Automated Patch Clamp Recordings of Human Stem Cell- Derived Cardiomyocytes.

icon pl  Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) book chapter in Stem Cell-Derived Models in Toxicology (2017)

Authors: 
Obergrussberger A., Haarmann C., Stölzle-Feix S., Becker N., OhtsukiA., Brüggemann A., George M., Fertig N.

2016 - Use-dependent Block of Human Cardiac Sodium Channels by GS967

icon sp96  SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Molecular Pharmacology (2016)

Authors: 
Potet F., Vanoye C.G., George Jr. A.L.

2016 - pH-sensitive K+ channel TREK-1 is a novel target in pancreatic cancer

icon sp96  SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Biochimica et Biophysica Acta (2016)

Authors: 
Sauter D.R.P., Sørensen C.E., Rapedius M., Brüggemann A., Novak I.

2016 - Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module

icon sp96  SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Journal of Lab Automation (2016)

Authors: 
Obergrussberger A., Brüggemann A., Goetze T.A., Rapedius M., Haarmann C., Rinke I., Becker N., Oka T., Ohtsuki A., Stengel T., Vogel M., Steindl J., Mueller M., Stiehler J., George M., Fertig N.

2015 - Novel screening techniques for ion channel targeting drugs

icon pl  Patchliner,   icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) and   Icon CE   CardioExcyte 96 publication in Channels (2015)

Authors: 
Obergrussberger A., Stölzle-Feix S., Becker N., Brüggemann A., Fertig N., Möller C.

2015 - Electrophysiological analysis of mammalian cells expressing hERG using automated 384-well-patch-clamp

icon sp96  SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in BCM Pharmacology and Toxicology (2015) 

Authors: 
Haraguchi Y., Ohtsuki A., Oka T., Shimizu T.

2014 - New strategies in ion channel screening for drug discovery: are there ways to improve its productivity?

icon sp96  SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Journal of Laboratory Automation (2014)

Authors: 
Farre C., Fertig N.

2014 - Early identification of hERG liability in drug discovery programs by automated patch clamp

icon pl  Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Frontiers in Pharmacology (2014)

Authors: 
Danker T., Moeller C.

2012 - Natural and artificial ion channels for biosensing platforms

icon pap   Port-a-Patch,   icon pl   Patchliner,   icon sp96   SyncroPatch 96 ((a predecessor model of SyncroPatch 384PE) and   icon vpp   Vesicle Prep Pro publication in Analytical and Bioanalytical Chemistry (2012)

Authors: 
Steller L., Kreir M., Salzer R.

2012 - HTS techniques for patch clamp-based ion channel screening - economy and advances

icon pap   Port-a-Patch,   icon pl   Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) publication in Expert Opinion on Drug Discovery (2012)

Authors: 
Farre C. and Fertig N.

2011 - State-of-the-art automated patch clamp devices: heat activation, action potentials, and high throughput in ion channel screening

icon pap   Port-a-Patch,   icon pl  Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) publication in Frontiers in Pharmacology (2011)

Authors: 
Stoelzle S., Obergrussberger A., Brüggemann A., Haarmann C., George M., Kettenhofen R., Fertig N.

2011 - Automated electrophysiology makes the pace for cardiac ion channel safety screening

icon pl  Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) publication in Frontiers in Pharmacology (2011)

Authors: 
Möller C., Witchel H.

2010 - Renaissance of ion channel research and drug discovery by patch clamp automation

icon pap  Port-a-Patch,   icon pl   Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE)  publication in Future Medical Chemistry (2010)

Authors:
Farre C. and Fertig N.

Product Sheets

SyncroPatch 384 - Product Sheet

icon sp96   SyncroPatch 384 product sheet:   logo pdf   (3.6 MB)

Posters

2021 - Reliable identification of cardiac liability in drug discovery using automated patch clamp: Considerations and best practices for high throughput recordings of NaV 1.5

icon pl   Patchliner and   icon sp96  SyncroPatch 384i (a predecessor model of SyncroPatch 384) Physiology 2021  logo pdf   (2 MB)

2021 - Development and validation of ASIC1a ligand-gated ion channel drug discovery assays on automated patch clamp platforms

icon pl   Patchliner and   icon sp96  SyncroPatch 384i (a predecessor model of SyncroPatch 384) Biophysical Society Meeting 2021  logo pdf   (2 MB)

2021 - Activation and inhibition of assay-ready TRPA1 and TRPV cells: an automated patch clamp study

icon pap Port-a-Patch, icon pl   Patchliner and   icon sp96  SyncroPatch 384i (a predecessor model of SyncroPatch 384) Biophysical Society Meeting 2021  logo pdf   (1.5MB)

2020 - Reliable Identification of hERG Liability in Drug Discovery by Automated Patch Clamp

 icon sp96   SyncroPatch 384i (a predecessor model of SyncroPatch 384) and   icon pl   Patchliner poster, 64th Annual Meeting of the Biophysical Society   logo pdf   (1.3 MB)

2020 - Kinetic and pharmacological properties of P2X3 and P2X2/3 receptors

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) and   icon pl   Patchliner poster, 64th Annual Meeting of the Biophysical Society   logo pdf   (1.8 MB)

2020 - Unattended Screening Workflow in a 384-well Automated Patch Clamp System

 icon sp96   SyncroPatch 384i (a predecessor model of SyncroPatch 384) poster, Safety Pharmacology Society Virtual Meeting 2020   logo pdf   (2.6 MB)

2018 - Expression and pharmacology of GluA2-containing AMPA receptors in cell lines and stem cell-derived neurons

icon pap   Port-a-Patch,   icon pl   Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) poster, Europhysiology Meeting 2018  logo pdf   (0.9 MB)

2018 - Combining electrophysiology and contractility recordings for more complete assessment of hiPSC-CMs

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384),   icon pl   Patchliner and   Icon CardioExcyte 96 simpel RGB   CardioExcyte 96 poster, Europhysiology Meeting 2018  logo pdf   (1.4 MB)

2017 - lnvestigation of the Ion Channels hTMEM16A/Ano1 and TRPC5 and their Modulation by Intracellular Calcium

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) poster, BPS Meeting 2017  logo pdf   (1.3 MB)

2017 - Activation of CFTR channels in absence of internal fluoride using a highly parallel automated patch clamp system

icon sp96   SyncroPatch 384PE  (a predecessor model of the SyncroPatch 384) poster, BPS Meeting 2017  logo pdf   (1.5 MB)

2017 - Cardiomyocytes in Voltage Clamp and Current Clamp by Automated Patch Clamp

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) and   icon pl   Patchliner poster, BPS Meeting 2017  logo pdf   (1.7 MB)

2018 - Investigating pain pathways by inhibition of voltage-gated sodium channels

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) and   icon pl   Patchliner poster, FENS Meeting 2018  logo pdf   (2.5 MB)

2017 - Pharmacological Characterization of the NMDA A-B-C by Automated Patch Clamp

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) poster, BPS Meeting 2017  logo pdf   (4.9 MB)

2018 - High throughput automatic patch clamp: Applications for Safety Pharmacology

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) poster, JSPS Meeting 2018  logo pdf   (2.3 MB)

2018 - Optogenetic technologies enable high throughput ion channel drug discovery and toxicity screening

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) and   Icon CE   CardioExcyte 96 poster, Biophysics Annual Meeting 2018  logo pdf   (1.3 MB)

2016 - Next level toxicity screening: From single channel to overall cell behavior

Icon Orbit Mini   Orbit mini,   Icon CE   CardioExcyte 96 and   icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) poster, Meeting of the French Society of Toxinology (SFET) 2015  logo pdf   (0.9 MB)

2015 - Organellar Transporters and Ion Channels - How to access their electrophysiology by using the SURFE2R technology and Planar Patch Clamp

Icon N1   SURFE²R N1 and   icon sp96   SyncroPatch 96 (a predecessor model of the SyncroPatch 384) and   icon pap   Port-a-Patch poster, GRC - Organellar Channels and Transporters 2015   logo pdf   (1.6 MB)

2015 - The backstage pass to study your favorite TRP channel

icon pap   Port-a-Patch and   icon pl   Patchliner and  icon sp96   SyncroPatch 384PE  (a predecessor model of the SyncroPatch 384) poster, TRP Meeting 2015   logo pdf   (2.2 MB)

2015 - High Throughput Automated Patch Clamp of Ion Channels Important in Cardiac Safety and Drug Discovery

icon sp96  SyncroPatch 384PE (a predecessor model of SyncroPatch 384) poster, Chantest Meeting 2015   logo pdf   (1.9 MB)

2015 - Complementary automated patch clamp, extracellular field potential and impedance recordings of iPSCs: safety screening tool box for the future

icon pl   Patchliner and   Icon CE   CardioExcyte 96 and   icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) poster,   SPS 2015   logo pdf   (2.7 MB)

Presentations

2020 - High Throughput screening of missense variants in KCNH2

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384) presentation (slide deck)  logo pdf (3 MB)

2018 - Innovations for cell monitoring in safety and toxicity assays

Icon CE   CardioExcyte 96 &   icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) presentation (slide deck)   logo pdf   (3.2 MB)

                      


Back to Overview

 

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.