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25.06.2021 | Peripheral Nerve Society Annual Meeting 2021

210625 PNS Angelika Poster Event

Conference Venue: Virtual Event 
Go to the Conference website here

Prof. Dr. Angelika Lampert ( Uniklinik RWTH Aachen) will present the following poster:

"α-Adrenoreceptor-Blocker Phentolamine MesylateInhibits Human Sodium Channels Nav1.7 and Nav1.5"

When: 25th June, 2021 at 13:00PM CEST 

Background: 

Phentolamine mesylate (PM) is an α-adrenoreceptor antagonist, inducing vasodilatation at its injection site. PM is injected as a reversal agent after treatment with soft-tissue local anesthesia and vasoconstrictors to avoid unwanted numbness. Previous studies suggested that PM may also interact with voltage-gated sodium channels (VGSC), like local anesthetics do.
We suggest outlines for best practices for recording NaV1.5 peak and late current using APC which include the use of the CiPA step-ramp protocol at physiological temperature, a minimum compound incubation time of 5 min, a replicate number of 4 and the use of positive and negative controls to ensure reliable IC50s.


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