25.06.2021 | Peripheral Nerve Society Annual Meeting 2021

Conference Venue: Virtual Event 
Go to the Conference website here

Prof. Dr. Angelika Lampert ( Uniklinik RWTH Aachen) will present the following poster:

"α-Adrenoreceptor-Blocker Phentolamine MesylateInhibits Human Sodium Channels Na_v1.7 and Na_v1.5"

When: 25th June, 2021 at 13:00PM CEST 

Background: 

Phentolamine mesylate (PM) is an α-adrenoreceptor antagonist, inducing vasodilatation at its injection site. PM is injected as a reversal agent after treatment with soft-tissue local anesthesia and vasoconstrictors to avoid unwanted numbness. Previous studies suggested that PM may also interact with voltage-gated sodium channels (VGSC), like local anesthetics do.
We suggest outlines for best practices for recording Na_V1.5 peak and late current using APC which include the use of the CiPA step-ramp protocol at physiological temperature, a minimum compound incubation time of 5 min, a replicate number of 4 and the use of positive and negative controls to ensure reliable IC₅₀s.

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