September 2021 - Automated patch clamp assay development for the study of red blood cells (RBCs) in health and disease
(PhD Candidate - Nanion Technologies )
Automated patch clamp assay development for the study of red blood cells (RBCs) in health and disease
Dr. Lars Kaestner
(Professor - Saarland University)
Introduction to EVIDENCE prognostic, diagnostic, and therapeutic approaches on RBC function in health and disease
Calcium (Ca2+) is a universal signaling molecule and is critically important in regulating many physiological functions and survival of RBCs. Amongst others, intracellular Ca2+ controls cell volume and deformability. This process plays a substantial role in RBCs since their volume needs to adapt when passing blood vessel constrictions during the flow. Excessive Ca2+ uptake also leads to accelerated cell clearance causing anaemia.
Therefore, studying Ca2+ regulation is crucial to understand RBC diseases. Piezo1, KCa3.1 (Gardos channel) and NMDA receptors are three channels present in the RBC membrane and critical for Ca2+ regulation.
We developed functional assays to measure these channels in healthy and diseased RBCs populations using electrophysiological tools, contributing to the characterization of RBC diseases.
Date: 07. September 2021
Time: 4PM CEST, 10AM EDT
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