TRPA1 - Temperature Dependency
Orbit mini data and applications:
(A) Effect of temperature on TRPA1 activity
(B) The open probability (Po) versus the temperature and fitted with Boltzmann equation (EC50 was found at 14˚C).
The Arrhenius plot of the same data resulted in a Q10 of 46 (Literature: Q10 ~ 40).
Nifedpinie is a dihydropyridine calcium channel blocker that primarily blocks L-type calcium channels. Impedance and EFP recordings on Cor.4U cells reveal a concentration dependent effect on impedance amplitude, beat rate and also a shortening of the FPD as expected.