• Orbit mini

    Simultaneous recording from four lipid bilayers

TRPA1 - Temperature Dependency

Icon Orbit Mini   Orbit mini data and applications:

Orbit Mini TRPA1

(A) Effect of temperature on TRPA1 activity
(B) The open probability (Po) versus the temperature and fitted with Boltzmann equation (EC50 was found at 14˚C).

The Arrhenius plot of the same data resulted in a Q10 of 46 (Literature: Q10 ~ 40).

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Nifedpinie is a dihydropyridine calcium channel blocker that primarily blocks L-type calcium channels. Impedance and EFP recordings on Cor.4U cells reveal a concentration dependent effect on impedance amplitude, beat rate and also a shortening of the FPD as expected.

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