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    Most versatile automated patch clamp system on the market
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    More than 10 years experience in assay design and support
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hERG - Pharmacology of Sotalol, Terfenadine, Verapamil (Results CiPA Phase I Study)

icon pl   CiPA PL phase 1 results 3Patchliner data and applications:
Cells were kindly provided by Charles River.

The effect of four compounds on hERG currents were investigated, using the CiPA voltage step protocol. Measured on the Patchliner the perforated patch methodology (Escin) and multi-hole chips (4 holes per well) were used. The IC50 value of Sotalol was determined as 157 µM, Terfenadine as 82.8 nM and Verapamil as 485 nM.

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