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    Most versatile automated patch clamp system on the market
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    In-house production and QC of consumables
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    More than 10 years experience in assay design and support
  • Dynamite8

    Automated Dynamic Clamp
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    All features & benefits of manual patch clamp

TRPC1 (Smooth Muscle Cells) - Pharmacology

PL TRP SMCicon pl   Patchliner data and applications: 
Data are taken from Li, J. et al., Circulation Research, 2008,103(8), e97-104.

(a) Example whole cell recording showing current evoked by extracellular application of 2 μM thapsigargin (TG) and subsequent inhibition by 10 μM lanthanum (La3+). (b) As for (a) but showing the effect of 20 μg/ml anti-STIM1 antibody. (c) For the experiment shown in (b), curren voltage relationships for the current evoked by TG and blocked by anti-STIM1 antibody. (d) Mean currents normalized to pre-antibody values showing the effect of 20 μg/ml ani-STIM1 antibody and lack of effects for IgG or denatured anti-STIM1 antibody.

 

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