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2011 - Pharmacological studies of Cav3.1 T-type calcium channels using automated patch-clamp techniques

icon pl  Patchliner publication in General Physiology and Biophysics (2011)

Authors: 
Choi K.-H., Song C., Cheong C.S., Rhim H.

 

Journal: 
Gen. Physiol. Biophys. (2011) 30(1):100-105


Abstract: 

T-type calcium channels are involved in a variety of physiological and pathophysiological processes, and thus could be therapeutic targets. However, there is no T-type channel selective blocker for use in clinical practice, demanding a need for the development of novel drugs where a higher-throughput screening system is required. Here we present pharmacological studies on Cav3.1 T-type channels using automated patch-clamp. The IC50 values obtained from automated patch-clamp and conventional one showed a good correlation (correlation coefficient of 0.82), suggesting that the automated patch-clamp is an efficient and reliable method for ranking the drug potencies for T-type channels.


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