Patchliner

Most versatile automated patch clamp system on the market
Patchliner

In-house production and QC of consumables
Patchliner

More than 10 years experience in assay design and support
Dynamite⁸

Automated Dynamic Clamp
Patchliner

All features & benefits of manual patch clamp

Acetylcholine Receptor Alpha 3 Beta 4 - Concentration Response Curve to Nicotine

Patchliner data and applications:

Shown are the a raw current responses of a HEK293 cell expressing AChR (α₃β₄) to increasing concentrations of nicotine. Solutions were stacked (layered) in the pipette to achieve brief exposure times.

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Patchliner Applications

Whole cell current responses of HEK293 cells expressing Na_V1.7 to increasing voltage steps from -60 mV to 50 mV with corresponding average IV curve.
Dynamite⁸ (dynamic clamp) used to model I_K1 on action potentials of hiPSC cardiomyocytes.
TRPV1 expressed in CHO cells activated by increasing temperature (top). TRPV1 activated by capsaicin or heated solution in the same cell (bottom).
Fast solution exchange and minimal exposure ensures reproducible recordings of nAChαR expressed in HEK cells and repetitive exposure to 100 μM nicotine.
hK_Ca3.1 (SK4) expressed in CHO cells was activated by internal application of Ca²⁺.