Patchliner

Most versatile automated patch clamp system on the market
Patchliner

In-house production and QC of consumables
Patchliner

More than 10 years experience in assay design and support
Dynamite⁸

Automated Dynamic Clamp
Patchliner

All features & benefits of manual patch clamp

CFTR - "Effect of internal F- on activation of Cystic Fibrosis Transmembrane Conductance (CFTR) regulator by forskolin " (report)

Patchliner application report: (0.2 MB)

Aim:

The aim of this study was to investigate the effect of internal F^- on the activation of the cystic fibrosis transmembrane conductance regulator (CFTR) by forskolin in the whole cell patch clamp configuration. Experiments were conducted with Nanion’s fully automated patch clamp device, the Patchliner.

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Patchliner Applications

Whole cell current responses of HEK293 cells expressing Na_V1.7 to increasing voltage steps from -60 mV to 50 mV with corresponding average IV curve.
Dynamite⁸ (dynamic clamp) used to model I_K1 on action potentials of hiPSC cardiomyocytes.
TRPV1 expressed in CHO cells activated by increasing temperature (top). TRPV1 activated by capsaicin or heated solution in the same cell (bottom).
Fast solution exchange and minimal exposure ensures reproducible recordings of nAChαR expressed in HEK cells and repetitive exposure to 100 μM nicotine.
hK_Ca3.1 (SK4) expressed in CHO cells was activated by internal application of Ca²⁺.