Patchliner

Most versatile automated patch clamp system on the market
Patchliner

In-house production and QC of consumables
Patchliner

More than 10 years experience in assay design and support
Dynamite⁸

Automated Dynamic Clamp
Patchliner

All features & benefits of manual patch clamp

Acetylcholine Receptor Alpha 7 - Enhancement by NS1738

Patchliner data and applications:
Cells were kindly supplied by Galantos Pharma GmbH.

Concentration response curve for NS1738 co-applied with 300 μM ACh revealed an EC₅₀ = 2.6 ± 1.1 μM (n = 4). This is in excellent agreement with the literature (Timmermann et al, 2007, JPET 323: 294–307).

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Patchliner Applications

Whole cell current responses of HEK293 cells expressing Na_V1.7 to increasing voltage steps from -60 mV to 50 mV with corresponding average IV curve.
Dynamite⁸ (dynamic clamp) used to model I_K1 on action potentials of hiPSC cardiomyocytes.
TRPV1 expressed in CHO cells activated by increasing temperature (top). TRPV1 activated by capsaicin or heated solution in the same cell (bottom).
Fast solution exchange and minimal exposure ensures reproducible recordings of nAChαR expressed in HEK cells and repetitive exposure to 100 μM nicotine.
hK_Ca3.1 (SK4) expressed in CHO cells was activated by internal application of Ca²⁺.

NEW: Dynamite8

The Dynamite⁸is a fully automated dynamic clamp add-on integrating seamlessly into an 8-channel or 4-channel Patchliner.

Get more information in the section "Add-ons and Features".

Open the Product flyer here.

Find out more about our technology

Here you find a detailed description about the technology:

How it works

Questions?

Nadine Linkedin

Contact our specialist Dr. Nadine Becker (Product Manager of the Patchliner). Nadine is delighted to help you:

Nadine.Becker@nanion.de
or call: +49 89 2190 95-054
or connect via Linkedin

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Patchliner

Most versatile automated patch clamp system on the market

Patchliner

In-house production and QC of consumables

Patchliner

More than 10 years experience in assay design and support

Dynamite8

Automated Dynamic Clamp

Patchliner

All features & benefits of manual patch clamp

Acetylcholine Receptor Alpha 7 - Enhancement by NS1738

Dynamite⁸