Patchliner

Most versatile automated patch clamp system on the market
Patchliner

In-house production and QC of consumables
Patchliner

More than 10 years experience in assay design and support
Dynamite⁸

Automated Dynamic Clamp
Patchliner

All features & benefits of manual patch clamp

KCa1.1 (BK) - Activation by Internal Calcium

Patchliner data and applications:

Top: BK (K_Ca1.1) current voltage relationships in a single cell showing effects of changing the intracellular free Ca²⁺ concentration (15 nM, n = 9; 108 nM, n = 11; 316 nM, n = 11).

Bottom: Comparison of BK (K_Ca1.1) current voltage relationships obtained on a conventional patch clamp setup (closed circles, n = 10) and on the Patchliner (open circles, n = 11).
Data are taken from Milligan C.J. et al., Nature Protocols, 2009, 4(2), 244-255.

Back to Overview

Subscribe to Our Newsletter/ e-mail Announcements

Email address

First Name

Last Name

News

Find a Distributor

Request a Quote

Schedule a Demo

Technical Support

Contact

Patchliner Applications

Whole cell current responses of HEK293 cells expressing Na_V1.7 to increasing voltage steps from -60 mV to 50 mV with corresponding average IV curve.
Dynamite⁸ (dynamic clamp) used to model I_K1 on action potentials of hiPSC cardiomyocytes.
TRPV1 expressed in CHO cells activated by increasing temperature (top). TRPV1 activated by capsaicin or heated solution in the same cell (bottom).
Fast solution exchange and minimal exposure ensures reproducible recordings of nAChαR expressed in HEK cells and repetitive exposure to 100 μM nicotine.
hK_Ca3.1 (SK4) expressed in CHO cells was activated by internal application of Ca²⁺.