2020 - Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells

  Patchliner publication in Cell Communication and Signaling (2020)

Authors:
Bissinger R., Petkova-Kirova P., Mykhailova O., Oldenborg PA., Novikova E., Donkor D.A., Dietz T., Bhuyan A.A.M., Sheffield W.P., Grau M., Artunc F., Kaestner L., Acker J.P., Qadri S.M.

Journal:
Cell Communication and Signaling (2020) doi: 10.1186/s12964-020-00651-5

Abstract:

Thrombospondin-1 (TSP-1), a Ca²⁺-binding trimeric glycoprotein secreted by multiple cell types, has been implicated in the pathophysiology of several clinical conditions. Signaling involving TSP-1, through its cognate receptor CD47, orchestrates a wide array of cellular functions including cytoskeletal organization, migration, cell-cell interaction, cell proliferation, autophagy, and apoptosis. In the present study, we investigated the impact of TSP-1/CD47 signaling on Ca²⁺ dynamics, survival, and deformability of human red blood cells (RBCs).

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