• Patchliner

    Most versatile automated patch clamp system on the market
  • Patchliner

    In-house production and QC of consumables
  • Patchliner

    More than 10 years experience in assay design and support
  • Dynamite8

    Automated Dynamic Clamp
  • Patchliner

    All features & benefits of manual patch clamp

Cardiomyocytes - "Voltage and current clamp recordings of Cellartis hiPS-CM on Nanion’s Patchliner"

icon pl   Patchliner application note:   logo pdf   (0.5 MB)
Cells were kindly provided by Takara Bio Europe AB.  


Human induced pluripotent stem (iPS) cell-derived cardiomyocytes have the potential to provide the ultimate model system for identifying potential anti-arrythmic effects of drugs during routine safety screening. Takara Bio Europe AB is providing a human iPS cell-derived cardiomyocyte product line for use in testing the efficacy and safety of pharmaceutical therapies. The ability to characterize the ion channel profile of these cells and record action potentials at a reasonable throughput is essential to fully realise the potential of this kind of product line. Building on the success of recording stem cells on the Patchliner, Cellartis® hiPS-CM, human iPS cell-derived cardiomyocytes, have now been characterized on the Patchliner in the voltage and current clamp mode.
In this Application Note we present data using an 8-channel Patchliner. In the voltage clamp mode, voltage-dependent Na+ (NaV), K+ (KV) and Ca2+ (CaV) channel currents were recorded. As expected, action potentials could be elicited in the current clamp mode. Furthermore, spontaneous action potentials could be recorded as well.

Back to Overview

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.