• Port-a-Patch

    Smallest patch clamp setup in the world
  • Port-a-Patch

    Easy to learn - ideal for teaching
  • Port-a-Patch

    Records from cells, organelles and bilayers
  • Port-a-Patch

    First planar patch clamp device on the market
  • Port-a-Patch

    Ideal for internal solution exchange applications

2003 - Lighting up single ion channels

icon pap  Port-a-Patch publication in Biophysical Journal (2003)

Authors: 
Selvin P.R.

 

Journal: 
Biophys. J. (2003) 84:1-2


Abstract: 

The holy grail of ion channel studies is to produce an atomic scale movie of an ion channel at work, simultaneously observing conformational and electrical changes as ions flow through the protein. Significant milestones toward this goal include the x-ray crystallography work of Mackinnon et al., which gave us atomic-resolution snapshots of potassium (Zhou et al., 2001) and chloride channels (Dutzler et al., 2002), and patch clamping, which revolutionized the field by giving us the ability to measure ionic currents through single ion channels.


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