• Port-a-Patch

    Smallest patch clamp setup in the world
  • Port-a-Patch

    Easy to learn - ideal for teaching
  • Port-a-Patch

    Records from cells, organelles and bilayers
  • Port-a-Patch

    First planar patch clamp device on the market
  • Port-a-Patch

    Ideal for internal solution exchange applications

2011 - Functional Analysis of Synthetic Substructures of Polytheonamide B: A Transmembrane Channel-Forming Peptide

icon pap   Port-a-Patch publication in Angewandte Chemie International Edition (2011)

Authors: 
Matsuoka S., Shinohara N., Takahashi T., Iida M., Inoue M.

 

Journal: 
Angew. Chem. Int. Ed. (2011) 50:4879-4883


Abstract: 

Polytheonamide B, the largest nonribosomal linear peptide identified to date, is a transmembrane channel-forming peptide. Nine of its substructures have now been chemically synthesized. The membrane-disrupting and ion-channel-forming sequences as well as the cytotoxicity-enhancing sequence have been identified.


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