hERG - Good Results with "Sticky Compounds"
Port-a-Patch data and applications:
Cells were kindly provided by Cytomyx/Millipore.
Sticky compounds, such as some hERG blockers, exhibit expected IC50 values with the Port-a-Patch. The concentrations of the half maximal block were: 1.27 nM (astemizole), 8.9 nM (cisapride), 163.7 nM (flunarizine) and 11.0 nM (terfenadine).