KV1.3 - Internal Application of TEA and Quinidine

  Port-a-Patch data and applications:

K_V1.3 current was blocked by the internal application of increasing concentrations of quinidine (left) or TEA⁺ (right). For quinidine the IC₅₀ was determined as 15 μM (literature value external application 14 μM) and for TEA⁺ the IC₅₀ was determined as 0.9 ± 0.3 mM (n = 3) (literature value internal application 0.6 mM).

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