2019 - Role of High‐Throughput Electrophysiology in Drug Discovery
SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i), Patchliner and Port-a-Patch review article in Current Protocols in Pharmacology (2019)
Liu C., Li T., Chen J.
Current Protocols in Pharmacology (2019) https://doi.org/10.1002/cpph.69
Due to their important physiological functions, ion channels are key therapeutic targets for a variety of disorders. However, electrophysiological assessment of ion channel activity is technically challenging and has been a bottleneck in the discovery of drugs that modulate channel function. To address this issue, automated patch clamp platforms have been developed with improved throughput and broader applications. An overview of the current status of high‐throughput electrophysiology and its applications in drug discovery is provided.