• SURFE²R 96SE

    Fully automated data recording and analysis. 10,000 data points per day!
  • SURFE²R 96SE

    First high throughput instrument on the market for SSM-based electrophysiology
  • SURFE²R 96SE

    Finally high throughput label-free functional assays for transporters available
  • SURFE²R 96SE

    High signal amplification compared to patch-clamp: transport & binding assays
  • SURFE²R 96SE

    Turn-key system for efficient transporter protein analysis

Amino Acid transporter - "Secondary screening assay for amino acid transporter inhibitors on the SURFE2R 96SE"

Icon 96SE   SURFE2R 96SE application note   logo pdf   (0.5 MB)

 Summary:

Na-dependent amino acid transporters play an essential role in the uphill transport of amino acids across the plasma membrane. In this study, a novel transporter target was used for which few specific pharmacological tools are available. The aim of this study was to establish a secondary screening assay using the direct electrophysiological measurement of the transporter to identify inhibitors. Using the SURFE2R 96SE, substrate specificity was determined and inhibitors could be identified. 

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