• SURFE²R 96SE

    Fully automated data recording and analysis. 10,000 data points per day!
  • SURFE²R 96SE

    First high throughput instrument on the market for SSM-based electrophysiology
  • SURFE²R 96SE

    Finally high throughput label-free functional assays for transporters available
  • SURFE²R 96SE

    High signal amplification compared to patch-clamp: transport & binding assays
  • SURFE²R 96SE

    Turn-key system for efficient transporter protein analysis

2020 - Drug effects on human Na+/Ca2+ exchanger and implications for testing new drug candidates

 Icon N1  SURFE²R N1 and   Icon 96SE   SURFE²R 96SE poster, Safety Pharmacology Society Virtual Meeting 2020   logo pdf   (1.2 MB)

Abstract:

The Na+/Ca2+-exchanger (NCX) plays an important role in cellular calcium homeostasis. Under physiological conditions NCX removes Ca2+ from the cell lumen of excitable cells and is involved in regulatory processes. Under pathological conditions, NCX can reverse direction and contribute to cell damage by Ca2+ overloading. These critical functions have fueled the debate over the pharmacological potential of NCX since many years. Inhibition of the reversed mode of NCX is thought to be beneficial in ischemia/reperfusion injury. Moreover, inhibition of NCX has been proposed to exhibit an antiarrhythmic effect. On the other hand the risk of inadvertent NCX inhibition as a secondary drug effect is poorly investigated and unspecific NCX inhibition is usually not tested during drug development.

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