• Research Ins]i[ghts: Nanion’s Transporter Webinar Series 2021
    Register for Session 5 Here

  • SURFE²R 96SE

    Fully automated data recording and analysis. 10,000 data points per day!
  • SURFE²R 96SE

    First high throughput instrument on the market for SSM-based electrophysiology
  • SURFE²R 96SE

    Finally high throughput label-free functional assays for transporters available
  • SURFE²R 96SE

    High signal amplification compared to patch-clamp: transport & binding assays
  • SURFE²R 96SE

    Turn-key system for efficient transporter protein analysis

2021 - An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters

Icon N1   SURFE²R N1 and   Icon 96SE   SURFE²R 96SE review publication in Frontiers in Pharmacology (2021)

Authors:
Dvorak V., Wiedmer T., Ingles-Prieto A., Altermatt P., Batoulis H., Bärenz F., Bender E., Digles D., Dürrenberger F., Heitman L.H., IJzerman A.P., Kell D.B., Kickinger S., Körzö D., Leippe P., Licher T., Manolova V., Rizzetto R., Sassone F., Scarabottolo L., Schlessinger A., Schneider V., Sijben H.J., Steck A-L., Sundström H., Tremolada S., Wilhelm M., Wright Muelas M., Zindel D., Steppan C-M., Superti-Furga G.

 

Journal:
Frontiers in Pharmacology (2021) doi:10.3389/fphar.2021.722889


Abstract:

The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and druggable targets, the majority of SLCs remains understudied. One major hurdle in research on SLCs is the lack of tools, such as cell-based assays to investigate their biological role and for drug discovery. Another challenge is the disperse and anecdotal information on assay strategies that are suitable for SLCs. This review provides a comprehensive overview of state-of-the-art cellular assay technologies for SLC research and discusses relevant SLC characteristics enabling the choice of an optimal assay technology. The Innovative Medicines Initiative consortium RESOLUTE intends to accelerate research on SLCs by providing the scientific community with high-quality reagents, assay technologies and data sets, and to ultimately unlock SLCs for drug discovery.


Download here

Back to Overview

 

 

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.