Research Ins]i[ghts: Nanion’s Transporter Webinar Series 2021
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SURFE²R 96SE

Fully automated data recording and analysis. 10,000 data points per day!
SURFE²R 96SE

First high throughput instrument on the market for SSM-based electrophysiology
SURFE²R 96SE

Finally high throughput label-free functional assays for transporters available
SURFE²R 96SE

High signal amplification compared to patch-clamp: transport & binding assays
SURFE²R 96SE

Turn-key system for efficient transporter protein analysis

PepT1 - Pharmacology of Losartan

SURFE²R N96 (a predecessor model of SURFE²R S96) data and applications:

Transport by PepT1 is inhibited by the kompetitive antagonist Losartan. When activated with 20 mM Gly-Gly, the IC₅₀ of Losartan was 80.4 µM. Data were analysed with DataControl - the Analysis software tool for recordings on the SURFE²R N96 and SyncroPatch 96/ 384PE.

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SURFE²R 96SE Applications

Substrate specifity of OCT2. Three different substrates are provided in increasing concentrations cumulatively in each well. Duration 30 minutes, CHO cell membrane preparation.
Sensor stability over time. The same assay was repeated at different time intervals. The signal was stable over 30 measurements and 12 hours.
Inhibition of PepT1. IC₅₀ determination of Lys[Z(NO2)]-Val with five concentrations. One concentration per 16 wells (n=16). Duration 15 minutes, CHO cell membrane preparation.
Interface of DataControl Software. The 96 datasets can be analyzed within minutes including statistical calculations, a pdf report and the option to export the data.
Screening of 6 inhibitors for EAAC1. After negative control and full activation of the transporter, different concentrations of inhibitor were used. At the end the full activation was repeated.

Instrument Grant Awards

Nanion Technologies GmbH will provide a complete instrument (SURFE²R N1) for a 6-month period

Learn more the Research Grants.

Find out more about our technology

Here you find a detailed description about the technology:

How it works

Questions?

Maria Barthmes Linkedin

Contact our specialist Dr. Maria Barthmes (Product Manager of the SURFE²R product family). Maria is delighted to help you:

Maria.Barthmes@nanion.de
or call: +49 89 2190 95-068
or connect via Linkedin

SURFE²R 96SE Services

We are offering SURFE²R 96SE maintenance contracts, in house trainings and assay development.

For more information: info@nanion.de

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More information

SURFE²R 96SE

Fully automated data recording and analysis. 10,000 data points per day!

SURFE²R 96SE

First high throughput instrument on the market for SSM-based electrophysiology

SURFE²R 96SE

Finally high throughput label-free functional assays for transporters available

SURFE²R 96SE

High signal amplification compared to patch-clamp: transport & binding assays

SURFE²R 96SE

Turn-key system for efficient transporter protein analysis

PepT1 - Pharmacology of Losartan