KV1.5 - Dose response curve of 4-AP
SyncroPatch 384PE (a predecessor model of SyncroPatch 384) data and applications:
Cells were kindly provided by Charles River.
Screenshots of the PatchControl 384 software showing a dose-response curve of 4-AP on KV1.5 stably transfected cells. Measured on the SyncroPatch 384PE (a predecessor model of SyncroPatch 384) using multi-hole chips (4 holes per well), the success rate of completed exeriments was 100%. The IC50 value of 160 µM corresponds well to literature (IC50 4-AP: 270 µM; Gutman et al., Pharmacological Reviews 57: 473-508, 2005).