KV1.5 - Dose response curve of 4-AP

  SyncroPatch 384PE (a predecessor model of SyncroPatch 384) data and applications:
Cells were kindly provided by Charles River.

Screenshots of the PatchControl 384 software showing a dose-response curve of 4-AP on K_V1.5 stably transfected cells. Measured on the SyncroPatch 384PE (a predecessor model of SyncroPatch 384) using multi-hole chips (4 holes per well), the success rate of completed exeriments was 100%. The IC₅₀ value of 160 µM corresponds well to literature (IC₅₀ 4-AP: 270 µM; Gutman et al., Pharmacological Reviews 57: 473-508, 2005). 

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