KV4.3/KChIP2 - Dose-response curve of Flecanaide

  SyncroPatch 384PE (a predecessor model of SyncroPatch 384) data and applications:
Cells were kindly provided by Charles River.

Screenshots of the PatchControl 384 software showing K_V4.3/KChIP2 current traces in response to a voltage step protocol and the corresponding current-voltage relationship plot. Using whole cell mode in combination with multi-hole chips (4 holes per well), stably transfected cells were measured on the SyncroPatch 384PE (a predecessor model of SyncroPatch 384). The IC₅₀ value of flecainide was determined as 28.3 µM which is in accordance to literature. The success rate of completed experiments was 100%. 

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