SyncroPatch 384

Next level versatility and flexibility
SyncroPatch 384

True HTS and GigaOhm seals
SyncroPatch 384

Your multi purpose instrument
SyncroPatch 384

Powerful analysis software
SyncroPatch 384

Assay flexibility via high tech
SyncroPatch 384

Heating and cooling of solutions, cells and patch clamp sites

KV4.3/KChIP2 - Dose-response curve of Flecanaide

SyncroPatch 384PE (a predecessor model of SyncroPatch 384) data and applications:
Cells were kindly provided by Charles River.

Screenshots of the PatchControl 384 software showing K_V4.3/KChIP2 current traces in response to a voltage step protocol and the corresponding current-voltage relationship plot. Using whole cell mode in combination with multi-hole chips (4 holes per well), stably transfected cells were measured on the SyncroPatch 384PE (a predecessor model of SyncroPatch 384). The IC₅₀ value of flecainide was determined as 28.3 µM which is in accordance to literature. The success rate of completed experiments was 100%.

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SyncroPatch 384

For all your patch clamp needs
The SyncroPatch 384 takes the versatility and flexibility of automated patch clamping to new levels.
Download the interactive guide

SyncroPatch 384 Applications

Temperature Control

Temperature controlled deck positions, cell hotel and patch clamp module. For cooling and heating.
Temperature Control

Measurement site, cells and solutions can be accurately temperature controlled – suits any target, e.g. cold regulated TRP channels like TRPM8.
32-well Mode

A small fraction of the chip can be used at a time, which is ideal for smaller compound screens. Take even more advantage of the economical price of the NPC-384 chip!
Benchmarking Cardiac Safety

Control recordings of hERG using the CiPA step-ramp protocol and 7 minute incubation time.
Speed is key

The faster you apply the ligand, the shorter is the Time to Peak. Pipetting speed is relevant for accurate pharmacology.