NaV1.9 - Pharmacology

    SyncroPatch 384/768 PE (a predecessor model of the SyncroPatch 384) data and applications:
Cells were kindly provided by Icagen.

Screenshots of the PatchControl 384 software showing hNa_V1.9 current traces in response to a voltage step protocol. Measured on the SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) using perforated patch methodology (Escin) and multi-hole chips (4 holes per well), the success rate of valuable data for the analysis was  86%. Na_V1.9 is TTX insensitive. The IC₅₀ value of lidocaine of the peak current was determined as 350 µM (Literature: 356 µM), the IC₅₀ value of tetracaine of the peak current was determined as 12.5 µM (Literature: 32 µM).

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