SyncroPatch 384

Next level versatility and flexibility
SyncroPatch 384

True HTS and GigaOhm seals
SyncroPatch 384

Your multi purpose instrument
SyncroPatch 384

Powerful analysis software
SyncroPatch 384

Assay flexibility via high tech
SyncroPatch 384

Heating and cooling of solutions, cells and patch clamp sites

NaV1.7 - Pharmacology of Lidocaine

SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) data and applications:
Cells were kindly provided by Anaxon.

The effect of different concentrations of Lidocaine on Na_V1.7 currents were investigated. Measured on the SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) the whole cell patch methodology and single-hole chips were used. The success rate of > 90% for cells which had a seal resistance > 500 MΩ was determined. A value of 0.79 was calculated for the z-factor (characterization of HTS screening assay quality).

Back to Overview

Find a Distributor

Request a Quote

Schedule a Demo

Technical Support

Contact

SyncroPatch 384

For all your patch clamp needs
The SyncroPatch 384 takes the versatility and flexibility of automated patch clamping to new levels.
Download the interactive guide

SyncroPatch 384 Applications

Temperature Control

Temperature controlled deck positions, cell hotel and patch clamp module. For cooling and heating.
Temperature Control

Measurement site, cells and solutions can be accurately temperature controlled – suits any target, e.g. cold regulated TRP channels like TRPM8.
32-well Mode

A small fraction of the chip can be used at a time, which is ideal for smaller compound screens. Take even more advantage of the economical price of the NPC-384 chip!
Benchmarking Cardiac Safety

Control recordings of hERG using the CiPA step-ramp protocol and 7 minute incubation time.
Speed is key

The faster you apply the ligand, the shorter is the Time to Peak. Pipetting speed is relevant for accurate pharmacology.