SyncroPatch 384

Next level versatility and flexibility
SyncroPatch 384

True HTS and GigaOhm seals
SyncroPatch 384

Your multi purpose instrument
SyncroPatch 384

Powerful analysis software
SyncroPatch 384

Assay flexibility via high tech
SyncroPatch 384

Heating and cooling of solutions, cells and patch clamp sites

P2X2/ P2X3 - Activation by ATP on the SyncroPatch 384PE

SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) data and applications:
Cells were kindly supplied by Axxam

P2X_2/3 recorded from CHO cells on the SyncroPatch 384PE (a predecessor model of the SyncroPatch 384). P2X_2/3 was activated by increasing concentrations of ATP with an EC₅₀ = 1.1 µM (n = 191). ATP was applied for approximately 1.5 s using the ‘Ligand Puff’ function of the SyncroPatch 384PE. Average traces and concentration response curve shown for 191 cells. Success rate was 99% for completed experiment (191 wells from a possible 192). Multi-hole (4 holes per well) chips were used.

Back to Overview

Find a Distributor

Request a Quote

Schedule a Demo

Technical Support

Contact

SyncroPatch 384

For all your patch clamp needs
The SyncroPatch 384 takes the versatility and flexibility of automated patch clamping to new levels.
Download the interactive guide

SyncroPatch 384 Applications

Temperature Control

Temperature controlled deck positions, cell hotel and patch clamp module. For cooling and heating.
Temperature Control

Measurement site, cells and solutions can be accurately temperature controlled – suits any target, e.g. cold regulated TRP channels like TRPM8.
32-well Mode

A small fraction of the chip can be used at a time, which is ideal for smaller compound screens. Take even more advantage of the economical price of the NPC-384 chip!
Benchmarking Cardiac Safety

Control recordings of hERG using the CiPA step-ramp protocol and 7 minute incubation time.
Speed is key

The faster you apply the ligand, the shorter is the Time to Peak. Pipetting speed is relevant for accurate pharmacology.