• SyncroPatch 384

    Next level versatility and flexibility
  • SyncroPatch 384

    True HTS and GigaOhm seals
  • SyncroPatch 384

    Your multi purpose instrument
  • SyncroPatch 384

    Powerful analysis software
  • SyncroPatch 384

    Assay flexibility via high tech
  • SyncroPatch 384

    Heating and cooling of solutions, cells and patch clamp sites

P2X2/ P2X3 - Activation by ATP on the SyncroPatch 384PE

P2X23 CHOCells ATP SP384icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) data and applications: 
Cells were kindly supplied by Axxam

P2X2/3 recorded from CHO cells on the SyncroPatch 384PE (a predecessor model of the SyncroPatch 384). P2X2/3 was activated by increasing concentrations of ATP with an EC50 = 1.1 µM (n = 191). ATP was applied for approximately 1.5 s using the ‘Ligand Puff’ function of the SyncroPatch 384PE. Average traces and concentration response curve shown for 191 cells. Success rate was 99% for completed experiment (191 wells from a possible 192). Multi-hole (4 holes per well) chips were used.

 

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