07.09.2021 | Webinar: Automated patch clamp assay development for the study of red blood cells (RBCs) in health and disease
SyncroPatch 384, Patchliner, Port-a-Patch Webinar
Date: September 07. 2021, 4:00 PM CEST (10:00 AM EDT)
Calcium (Ca2+) is a universal signalling molecule and is critically important in regulating many physiological functions and survival of RBCs. Amongst others, intracellular Ca2+ controls cell volume and deformability. This process plays a substantial role in RBCs since their volume needs to adapt when passing blood vessel constrictions during the flow. Excessive Ca2+ uptake also leads to accelerated cell clearance causing anaemia.
Therefore, studying Ca2+ regulation is crucial to understand RBC diseases. Piezo1, KCa3.1 (Gardos channel) and NMDA receptors are three channels present in the RBC membrane and critical for Ca2+ regulation.
We developed functional assays to measure these channels in healthy and diseased RBCs populations using electrophysiological tools, contributing to the characterization of RBC diseases.
(PhD Candidate - Nanion Technologies )
Automated patch clamp assay development for the study of red blood cells (RBCs) in health and disease
Dr. Lars Kaestner
(Professor - Saarland University)
Introduction to EVIDENCE prognostic, diagnostic, and therapeutic approaches on RBC function in health and disease