2022 - High performance automated patch-clamp characterisation of mammalian atrial cardiomyocytes
SyncroPatch 384 poster, Deutsche Gesellschaft für Kardiologie (German Cardiac Society) 2022 (2.02 MB)
Atrial fibrillation (AF) is the most commonly reported cardiac arrhythmia. Current AF therapeutics lack efficacy, and mechanistic models to examine ion channel remodelling in AF are limited by a lack of atrial specificity in expression systems or low throughput methodologies. Much progress has recently been made in the development of automated patch-clamp (APC) systems that allow for high throughput electrophysiological measurements. APC could therefore be a useful tool for increasing the throughput of experiments involving complex AF-induced ionic remodelling events.
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