• SyncroPatch 384/768i

    APC with highest throughput on the market
  • SyncroPatch 384/768i

    384 cells in parallel => upgradable to 768
  • SyncroPatch 384/768i

    True HTS AND Gigaohm seals
  • SyncroPatch 384/768i

    Analysis Software even more powerful than before
  • SyncroPatch 384/768i

    Assay flexibility via high tech

CaV1.3 - "Characterization of CaV1.3 on Nanion's SyncroPatch 96"

icon sp96   SyncroPatch 96 (a predecessor model of the SyncroPatch 384PE)   logo pdf   (0.5 MB)

Summary:

HEK-cells expressing CaV1.3 channels were investigated with the SyncroPatch 96. CaV1.3 is an L-type, high voltage activated (HVA) calcium channel found in certain neuronal dendrites. Four L-type voltage gated Ca2+ channels (LTCC) isoforms are known (CaV1.1, CaV1.2, CaV1.3, and CaV1.4). All of them are characterized by high sensitivity to dihydropyridine (DHP) Ca2+ channel modulators, although differences in their voltage-dependence of DHP block exist. Furthermore, they own different biophysical and pharmacological properties and different cellular distribution. The unique DHP sensitivity distinguishes them from other voltage-gated Ca2+ channel types. Gating differences are intrinsic properties of their pore-forming a-1 subunits which assemble with accessory a-2-d and b-subunits (in some tissues also a g-subunit) to form a functional channel.

Back to Overview

SyncroPatch 384i brochure

Cookies make it easier for us to provide you with our services. With the usage of our services you permit us to use cookies.
More information Ok