NaV1.5 - Lidocaine Dose Response
SyncroPatch384PE (a predecessor model of SyncroPatch 384i) data and applications:
Cells were kindly provided by EMD Millipore
NaV1.5 expressed in HEK293 cells recorded on the SyncroPatch 384PE. The concentration response curves for lidocaine block of NaV1.5 were constructied at different holding potential (as indicated) either using a single concentration of compound pera per cell (solid lines) or cumulative concentration response curves (dashed line). The IC50 for lidocaine was shifted by a factor of 35 when holding potential was changed from -120 mV to -80 mV.