• SyncroPatch 384/768i

    APC with highest throughput on the market
  • SyncroPatch 384/768i

    384 cells in parallel => upgradable to 768
  • SyncroPatch 384/768i

    True HTS AND Gigaohm seals
  • SyncroPatch 384/768i

    Analysis Software even more powerful than before
  • SyncroPatch 384/768i

    Assay flexibility via high tech

2020 - Unattended Screening Workflow in a 384-well Automated Patch Clamp System

 icon sp96   SyncroPatch 384i poster, Safety Pharmacology Society Virtual Meeting 2020   logo pdf   (2.6 MB)

Abstract:

Within ion channel working group efforts (Fermini et al., 2015), reference compounds were tested across multiple sites and automated patch clamp (APC) platforms (Kramer et al., 2020). Resulting IC50 values were variable between drugs and platforms. In general, as Iversen et al. (2012) outlined, the quality of an assay is defined by the robustness and reproducibility of the measurement signal in the absence of any test compounds. Data robustness and reliability using an APC instrumentation should be proven carefully before an unattended full-day screening workflow is implemented.

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SyncroPatch 384i brochure

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