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15.10.2020 | Webinar: ICH S7B best practices considerations - New Q&As and Benchmarking best practices

 icon pl Patchliner and  icon sp96 SyncroPatch 384i Webinar

Date: October 15. 2020

201012 Blog Image VUM 2020

Speakers:

Dr. Sonja Stoelzle-Feix (Nanion Technologies)

 


This is an on-demand webinar from Nan]i[on and Friends 2020.

Abstract:

The ICH E14/S7B Implementation Working Group released a draft version on August 28th 2020 on “Clinical and Nonclinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential Questions and Answers”. This document is open for public consultation and comprises proposed revisions for some sections of the current Q&A´s for ICH E14. Furthermore, new Q&A for ICH S7B are included.

This talk will focus on best practice outlines as depicted in the draft version, specifically on in vitro cardiac ion channel assays. The ultimate goal is to provide a more robust and reproducible evaluation of potency of drug block of cardiac ion channel current using patch clamp techniques and heterologous expression systems.


 

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