• SyncroPatch 384/768i

    APC with highest throughput on the market
  • SyncroPatch 384/768i

    384 cells in parallel => upgradable to 768
  • SyncroPatch 384/768i

    True HTS AND Gigaohm seals
  • SyncroPatch 384/768i

    Analysis Software even more powerful than before
  • SyncroPatch 384/768i

    Assay flexibility via high tech

2021 - Activation and inhibition of assay-ready TRPA1 and TRPV cells: an automated patch clamp study

icon pap Port-a-Patch, icon pl   Patchliner and   icon sp96  SyncroPatch 384i Biophysical Society Meeting 2021  logo pdf   (1.5MB)

Abstract:

Transient Receptor Potential (TRP) channels are widely distributed throughout the mammalian central and peripheral nervous systems. They can be directly activated by ligands, heat or cold and mechano-stimulation, and are important targets in drug discovery for the treatment of pain, respiratory diseases, cancer, immune disorders and others. Here, we studied the responses of TRPA1, TRPV1, TRPV3, TRPV4 and TRPM8 assay-ready and cultured cells activated using a variety of stimuli on automated patch clamp (APC) systems.

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