NaV1.8 - I/V Characteristics
SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) data and applications:
The CHO cells were kindly provided by Charles River.
Raw traces from an exemplar cell expressing hNaV1.8 recorded on the SyncroPatch 384PE. Shown are current responses to increasing voltage steps from -60 to +60 mV (left). Current-voltage plot for an average of 380 cells is shown on the right. Shown are mean of peak amplitudes normalized to the maximum of each cell ± S.E.M. The data was fitted using a Boltzmann equation revealing a Vhalf of activation of -2.7 mV (n = 380), in good agreement with the range found in the literature.